Rabbit GNA15 Polyclonal Antibody | anti-GNA15 antibody

GNA15 antibody

Cat. Num. AAA9413188

• Gene Names: GNA15; GNA16
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: GNA15; Polyclonal Antibody; GNA15 antibody; GNA16; anti-GNA15 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total GNA15 antibody.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 374

• Applicable Applications for anti-GNA15 antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500 - 1:2000
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human GNA15.
• Target Name: GNA15
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts of mouse heart tissue, using GNA15 antibody.)

Related Product Information for anti-GNA15 antibody

Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors (1). Each of a very broad range of receptors specifically detects an extracellular stimulus (a photon, pheromone, odorant, hormone or neurotransmitter) while the effectors (i.e., adenylyl cyclase), which act to generate one or more intracellular messengers, are less numerous. In mammals, G protein , ¡' and polypeptides are encoded by at least 16, 4 and 7 genes, respectively (2-5). Most interest in G proteins has been focused on their a subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Four distinct classes of G subunits have been identified; these include Gs, Gi, Gq and Ga 12/13 (3,4). The Gi class comprises all the known a subunits that are susceptible to pertussis toxin modifications, including Ga i-1, Ga i-2, Ga i-3, Ga o, Ga t1, Ga t2, Ga z and Ga gust (4). Of these, the three Ga i subtypes function to open atrial potassium channels (6). Ga 16 is a member of the Gq subfamily and is expressed specifically in hematopoietic cells (7).

Product Categories/Family for anti-GNA15 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 597709771
• NCBI GeneID: 2769
• NCBI Accession #: NP_002059.3
• NCBI GenBank Nucleotide #: NM_002068.3
• UniProt Accession #: P30679; O75247; Q53XK2; E9KL40; E9KL47
• Molecular Weight: 43,568 Da
• NCBI Official Full Name: guanine nucleotide-binding protein subunit alpha-15
• NCBI Official Synonym Full Names: guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
• NCBI Official Symbol: GNA15
• NCBI Official Synonym Symbols: GNA16
• NCBI Protein Information: guanine nucleotide-binding protein subunit alpha-15
• UniProt Protein Name: Guanine nucleotide-binding protein subunit alpha-15
• Protein Family: Guanine nucleotide-binding protein
• UniProt Gene Name: GNA15
• UniProt Synonym Gene Names: GNA16; G alpha-15; G-protein subunit alpha-15; G alpha-16; G-protein subunit alpha-16
• UniProt Entry Name: GNA15_HUMAN

Uniprot Description

G-alpha 15: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Belongs to the G-alpha family. G(q) subfamily.

Protein type: G protein, heterotrimeric; G protein; G protein, heterotrimeric alpha G(q)

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: plasma membrane; heterotrimeric G-protein complex

Molecular Function: GTPase activity; signal transducer activity; G-protein-coupled receptor binding; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; platelet activation; elevation of cytosolic calcium ion concentration; phospholipase C activation; metabolic process; dopamine receptor, phospholipase C activating pathway; blood coagulation; muscarinic acetylcholine receptor, phospholipase C activating pathway