Western Blot (WB)
(Western blot analysis of extracts from MCF7, using Fumarylacetoacetate hydrolase Antibody. The lane on the left was treated with blocking peptide.)
Rabbit Fumarylacetoacetate hydrolase Polyclonal Antibody | anti-FAH antibody
Fumarylacetoacetate hydrolase Antibody
Predicted Reactivity: Bovine(88%)
Predicted Reactivity: Bovine(88%)
ELISA(peptide): 1:20,000-1:40,000
Western Blot (WB)
(Western blot analysis of extracts from MCF7, using Fumarylacetoacetate hydrolase Antibody. The lane on the left was treated with blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from MCF7, using Fumarylacetoacetate hydrolase Antibody. The lane on the left was treated with blocking peptide.)
Subunit Structure: Homodimer.
Similarity: Belongs to the FAH family.
NCBI and Uniprot Product Information
Predicted Molecular Weight: (Calculated)46kDa.
NCBI Description
This gene encodes the last enzyme in the tyrosine catabolism pathway. FAH deficiency is associated with Type 1 hereditary tyrosinemia (HT). [provided by RefSeq, Jul 2008]
Uniprot Description
FAH: Defects in FAH are the cause of tyrosinemia type 1 (TYRO1). An inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and hepatorenal manifestations. Typical features include hepatic necrosis, renal tubular injury, episodic weakness, self-mutilation, and seizures. Renal tubular dysfunction is associated with phosphate loss and hypophosphataemic rickets. Progressive liver disease can lead to the development of hepatocellular carcinoma. Dietary treatment with restriction of tyrosine and phenylalanine alleviates the rickets, but liver transplantation has so far been the only definite treatment. Belongs to the FAH family.
Protein type: Amino Acid Metabolism - tyrosine; EC 3.7.1.2; Hydrolase
Chromosomal Location of Human Ortholog: 15q25.1
Cellular Component: cytosol
Molecular Function: fumarylacetoacetase activity; metal ion binding
Biological Process: L-phenylalanine catabolic process; tyrosine catabolic process; arginine catabolic process
Disease: Tyrosinemia, Type I
Research Articles on FAH
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Product Notes
The FAH fah (Catalog #AAA9612256) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Fumarylacetoacetate hydrolase Antibody reacts with Human, Mouse, Rat Predicted Reactivity: Bovine(88%) and may cross-react with other species as described in the data sheet. AAA Biotech's Fumarylacetoacetate hydrolase can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). WB: 1:500-1:2000 ELISA(peptide): 1:20,000-1:40,000. Researchers should empirically determine the suitability of the FAH fah for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Fumarylacetoacetate hydrolase, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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