Rabbit anti-Human, Mouse FPGT Polyclonal Antibody | anti-FPGT antibody

FPGT Rabbit Polyclonal

Cat. Num. AAA769448

• Gene Names: FPGT; GFPP
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: FPGT; Polyclonal Antibody; FPGT Rabbit Polyclonal; anti-FPGT antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 174

• Applicable Applications for anti-FPGT antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Fucose-1-phosphate guanylyltransferase
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human colon tissue slide using MBS769448 (FPGT Antibody) at dilution of 1:50)

Western Blot (WB)

(mouse colon tissue were subjected to SDS PAGE followed by western blot with MBS769448 (FPGT Antibody) at dilution of 1:600)

NCBI and Uniprot Product Information

• NCBI GI #: 118142833
• NCBI GeneID: 8790
• Molecular Weight: 19,170 Da
• NCBI Official Full Name: FPGT protein, partial
• NCBI Official Synonym Full Names: fucose-1-phosphate guanylyltransferase
• NCBI Official Symbol: FPGT
• NCBI Official Synonym Symbols: GFPP
• NCBI Protein Information: fucose-1-phosphate guanylyltransferase
• UniProt Protein Name: Fucose-1-phosphate guanylyltransferase
• Protein Family: Fucose-1-phosphate guanylyltransferase
• UniProt Gene Name: FPGT
• UniProt Synonym Gene Names: GFPP
• UniProt Entry Name: FPGT_HUMAN

NCBI Description

L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream TNNI3 interacting kinase (TNNI3K) gene. [provided by RefSeq, Dec 2010]

Uniprot Description

FPGT: Catalyzes the formation of GDP-L-fucose from GTP and L- fucose-1-phosphate. Functions as a salvage pathway to reutilize L- fucose arising from the turnover of glycoproteins and glycolipids. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 2.7.7.30; Carbohydrate Metabolism - fructose and mannose; Transferase

Chromosomal Location of Human Ortholog: 1p31.1

Cellular Component: cytoplasm; cytosol

Molecular Function: catalytic activity; fucose-1-phosphate guanylyltransferase activity; GTP binding

Biological Process: fucose metabolic process