Rabbit anti-Human FPGT Polyclonal Antibody | anti-FPGT antibody

Anti-FPGT Antibody IHC-plus

Cat. Num. AAA2400123

• Gene Names: FPGT; GFPP
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Caprylic acid and ammonium sulfate precipitation
• Synonyms: FPGT; Polyclonal Antibody; Anti-FPGT Antibody IHC-plus; Rabbit Polyclonal (IgG) to Human FPGT; Human FPGT; GDP-L-fucose diphosphorylase; GDP-L-fucose pyrophosphorylase; GFPP; anti-FPGT antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human FPGT
• Purity/Purification: Caprylic acid and ammonium sulfate precipitation
• Form/Format: PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
• Sequence Length: 607

• Applicable Applications for anti-FPGT antibody: Immunohistochemistry (IHC) Paraffin, Western Blot (WB), ELISA (EIA)
• Application Notes: IHC-P (10 ug/ml)
• Immunogen: FPGT antibody was raised against recombinant human Fucose-1-phosphate guanylyltransferase.
• Immunogen Description: Recombinant human Fucose-1-phosphate guanylyltransferase.
• Immunogen Type: Recombinant protein
• Target Species: Human
• Preparation and Storage: Long term: -20 degree C; Short term: 4 degree C; Avoid repeat freeze-thaw cycles

Immunohistochemistry - Paraffin (IHC)

(Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry - Paraffin (IHC)

(Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE))

Related Product Information for anti-FPGT antibody

FPGT Antibody, GDP-L-fucose diphosphorylase Antibody, GDP-L-fucose pyrophosphorylase Antibody, GFPP Antibody Description: L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose.

NCBI and Uniprot Product Information

• NCBI GI #: 510025466
• NCBI GeneID: 8790
• NCBI Accession #: NP_003829.3
• NCBI GenBank Nucleotide #: NM_003838.4
• UniProt Accession #: O14772; Q8N5J7; A6NMH3; B4DRX2; B4E2Y7; E9PNQ2
• Molecular Weight: 19,170 Da
• NCBI Official Full Name: fucose-1-phosphate guanylyltransferase isoform 1
• NCBI Official Synonym Full Names: fucose-1-phosphate guanylyltransferase
• NCBI Official Symbol: FPGT
• NCBI Official Synonym Symbols: GFPP
• NCBI Protein Information: fucose-1-phosphate guanylyltransferase
• UniProt Protein Name: Fucose-1-phosphate guanylyltransferase
• Protein Family: Fucose-1-phosphate guanylyltransferase
• UniProt Gene Name: FPGT
• UniProt Synonym Gene Names: GFPP
• UniProt Entry Name: FPGT_HUMAN

NCBI Description

L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream TNNI3 interacting kinase (TNNI3K) gene. [provided by RefSeq, Dec 2010]

Uniprot Description

FPGT: Catalyzes the formation of GDP-L-fucose from GTP and L- fucose-1-phosphate. Functions as a salvage pathway to reutilize L- fucose arising from the turnover of glycoproteins and glycolipids. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Carbohydrate Metabolism - fructose and mannose; Transferase; Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 2.7.7.30

Chromosomal Location of Human Ortholog: 1p31.1

Cellular Component: cytoplasm; cytosol

Molecular Function: catalytic activity; fucose-1-phosphate guanylyltransferase activity; GTP binding

Biological Process: cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; fucose metabolic process; post-translational protein modification; protein amino acid N-linked glycosylation via asparagine