Western Blot (WB)
(Western blot analysis of whole cell lysates from HeLa (H), Jurkat (J) and K562 (K) cell lines using MBS623794.)
Rabbit anti-Human FLIP-L Polyclonal Antibody | anti-FAIM3 antibody
FLIP-L (FLICE-like Inhibitory Protein Long Form, CFLAR, CASH, CASP8AP1, CLARP, MRIT, CASP8 and FADD-like Apoptosis Regulator, Caspase Homolog, CASH, Caspase-eight-related Protein, Casper, Caspase-like Apoptosis Regulatory Protein, CLARP, Cellular FLICE-li
Gene Names
FAIM3; FCMR; TOSO
Reactivity
Human
Applications
Western Blot, Immunohistochemistry
Purity
Purified by Ion exchange chromatography.
Synonyms
FLIP-L; Polyclonal Antibody; FLIP-L (FLICE-like Inhibitory Protein Long Form; CFLAR; CASH; CASP8AP1; CLARP; MRIT; CASP8 and FADD-like Apoptosis Regulator; Caspase Homolog; Caspase-eight-related Protein; Casper; Caspase-like Apoptosis Regulatory Protein; Cellular FLICE-li; Anti -FLIP-L (FLICE-like Inhibitory Protein Long Form; anti-FAIM3 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes the 55kD FLIPL protein, a FLICE inhibitory protein. Does not recognize FLIPS (FLIP short form).
Purity/Purification
Purified by Ion exchange chromatography.
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Concentration
0.5 mg/mL (varies by lot)
Applicable Applications for anti-FAIM3 antibody
Western Blot (WB), Immunohistochemistry-Frozen (IHC-Fr)
Application Notes
WB: 1:500-1:1000
Optimal dilutions to be determined by the researcher
Other applications not tested
Optimal dilutions to be determined by the researcher
Other applications not tested
Immunogen
Peptide at C-terminus of FLIP-L
Grade
Highly Purified
Preparation and Storage
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Western Blot (WB)
(Western blot analysis of whole cell lysates from HeLa (H), Jurkat (J) and K562 (K) cell lines using MBS623794.)
Western Blot (WB)
(Western blot analysis of whole cell lysates from HeLa (H), Jurkat (J) and K562 (K) cell lines using MBS623794.)
Immunocytochemistry (ICC)
(Immunocytochemistry analysis of Jurkat cells using MBS623794)
Immunocytochemistry (ICC)
(Immunocytochemistry analysis of Jurkat cells using MBS623794)
Related Product Information for anti-FAIM3 antibody
FLICE-inhibitory proteins (FLIP) are widely expressed apoptosis regulator proteins. FLIPs may function as a crucial link between cell survival and cell death pathways in mammalian cells. At least 14 isoforms of FLIP have been defined arising from alternative splicing. The long form FLIP-L contains a domain similar to those found in caspases.
FLIP was cloned independently in a number of laboratories and is also known as Casper, I-FLICE, FLAME-1, CASH and CLARP. FLIP has two death effector domains (DEDs) and a caspase-like domain. It interacts with FADD and caspase-8 and -10, potently inhibiting apoptosis by all known death receptors. FLIP exists in a short form (FLIPS) and a long form (FLIPL).
FLIP was cloned independently in a number of laboratories and is also known as Casper, I-FLICE, FLAME-1, CASH and CLARP. FLIP has two death effector domains (DEDs) and a caspase-like domain. It interacts with FADD and caspase-8 and -10, potently inhibiting apoptosis by all known death receptors. FLIP exists in a short form (FLIPS) and a long form (FLIPL).
Product Categories/Family for anti-FAIM3 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
fas apoptotic inhibitory molecule 3 isoform c
NCBI Official Synonym Full Names
Fas apoptotic inhibitory molecule 3
NCBI Official Symbol
FAIM3
NCBI Official Synonym Symbols
FCMR; TOSO
NCBI Protein Information
fas apoptotic inhibitory molecule 3; Fc mu receptor; IgM Fc receptor; immunoglobulin mu Fc receptor; regulator of Fas-induced apoptosis Toso
UniProt Protein Name
Fas apoptotic inhibitory molecule 3
UniProt Gene Name
FAIM3
UniProt Synonym Gene Names
TOSO
UniProt Entry Name
FAIM3_HUMAN
NCBI Description
Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]
Uniprot Description
FAIM3: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: integral to membrane; extracellular region
Biological Process: immune system process; cellular defense response; negative regulation of apoptosis
Research Articles on FAIM3
Similar Products
Product Notes
The FAIM3 faim3 (Catalog #AAA623794) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FLIP-L (FLICE-like Inhibitory Protein Long Form, CFLAR, CASH, CASP8AP1, CLARP, MRIT, CASP8 and FADD-like Apoptosis Regulator, Caspase Homolog, CASH, Caspase-eight-related Protein, Casper, Caspase-like Apoptosis Regulatory Protein, CLARP, Cellular FLICE-li reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FLIP-L can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry-Frozen (IHC-Fr). WB: 1:500-1:1000 Optimal dilutions to be determined by the researcher Other applications not tested. Researchers should empirically determine the suitability of the FAIM3 faim3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FLIP-L, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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