Western Blot (WB)
(Western Blot: Sample: Mouse Testis Tissue.)
Rabbit anti-Mouse Fibroblast Activation Protein Alpha Polyclonal Antibody | anti-FAPa antibody
Polyclonal Antibody to Fibroblast Activation Protein Alpha (FAPa)
Immunohistochemistry: 5-20 ug/mL;1:45-180
Immunocytochemistry: 5-20 ug/mL;1:45-180
Optimal working dilutions must be determined by end user
Store at 4ºC for frequent use.
Aliquot and store at -20ºC for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Western Blot (WB)
(Western Blot: Sample: Mouse Testis Tissue.)
Western Blot (WB)
(Western Blot: Sample: Mouse Testis Tissue.)
Western Blot (WB)
(Western Blot: Sample: Recombinant FAPa, Mouse.)
Western Blot (WB)
(Western Blot: Sample: Recombinant FAPa, Mouse.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Testis Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Testis Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Uterus Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Uterus Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Stomach Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Stomach Tissue.)
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the serine protease family. The encoded protein is an inducible cell-surface bound glycoprotein specifically expressed in tumor-associated fibroblasts and pericytes of epithelial tumors and has protease and gelatinase activity. The protein plays a role in remodeling of the extracellular matrix (ECM) and may affect tumorigenesis and tissue repair. Alternately spliced transcript variants of this gene are described in the literature (PMID 9139873), but the full-length sequence of these variants is not available. [provided by RefSeq, Apr 2013]
Uniprot Description
FAP: In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers. Belongs to the peptidase S9B family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.14.5; EC 3.4.21.26; Membrane protein, integral; Protease
Chromosomal Location of Human Ortholog: 2 C1.3|2 35.85 cM
Cellular Component: apical part of cell; cell junction; cell projection; cell surface; extracellular region; extracellular space; focal adhesion; integral component of membrane; invadopodium membrane; lamellipodium; membrane; plasma membrane
Molecular Function: dipeptidyl-peptidase activity; endopeptidase activity; hydrolase activity; integrin binding; peptidase activity; protease binding; protein homodimerization activity; serine-type endopeptidase activity; serine-type peptidase activity
Biological Process: angiogenesis; apoptosis; cell adhesion; endothelial cell migration; melanocyte apoptotic process; melanocyte proliferation; mitotic cell cycle arrest; negative regulation of extracellular matrix disassembly; positive regulation of cell cycle arrest; positive regulation of execution phase of apoptosis; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of collagen catabolic process
Research Articles on FAPa
Similar Products
Product Notes
The FAPa fap (Catalog #AAA2026729) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Fibroblast Activation Protein Alpha (FAPa) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Fibroblast Activation Protein Alpha can be used in a range of immunoassay formats including, but not limited to, WB; IHC; ICC; IP. Western blotting: 0.5-2 ug/mL;1:450-1800 Immunohistochemistry: 5-20 ug/mL;1:45-180 Immunocytochemistry: 5-20 ug/mL;1:45-180 Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the FAPa fap for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Fibroblast Activation Protein Alpha, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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