Rabbit FEZ2, IN Polyclonal Antibody | anti-FEZ2 antibody

FEZ2, IN (Fasciculation and elongation protein zeta 2, HUM3CL, MGC117372, Pre-T/NK cell-associated protein 3Cl, Zygin-2, Zygin II)

Cat. Num. AAA620708

• Gene Names: FEZ2; HUM3CL; MGC117372
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: FEZ2; IN; Polyclonal Antibody; IN (Fasciculation and elongation protein zeta 2; HUM3CL; MGC117372; Pre-T/NK cell-associated protein 3Cl; Zygin-2; Zygin II); Anti -FEZ2; anti-FEZ2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human FEZ2. Species crossreactivity: Mouse and rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-FEZ2 antibody: Western Blot (WB)
• Application Notes: Dilution: Western Blot: 0.5-1ug/ml
• Immunogen: Synthetic peptide corresponding to 15aa from near the center of human FEZ2 (Genbank accession No. NP_001036013).
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western blot analysis of Plxdc2 in human colon tissue lysate with Plxdc2 antibody at (A) 0.5 (B) 1 ug/ml.)

Related Product Information for anti-FEZ2 antibody

Fasciculation and elongation protein zeta-2 (FEZ2) is a homolog to the mammalian FEZ1, itself an ortholog of the C. elegans UNC-76 (1,2). In contrast to FEZ1, FEZ2 mRNA is widely expressed in mouse tissues. FEZ2 interacts with protein kinase C (PKC)- substrate and induces neurite extension of PC12 cells when co-expressed with a constitutively active form of PKC-, suggesting FEZ2 may play an important role in the morphological changes of various cells by associating with PKC- in a tissue non-specific manner (1). FEZ2 can interact with FEZ1 through its c- terminal regions and especially its coiled-coil region (5). At least two isoforms of FEZ2 are known to exist.

Product Categories/Family for anti-FEZ2 antibody

Antibodies; Abs to C. elegans Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 110349756
• NCBI GeneID: 9637
• NCBI Accession #: NP_001036013.1
• NCBI GenBank Nucleotide #: NM_001042548.1
• UniProt Accession #: Q0D2I6; Q3ZCX5; Q59EU2; Q6P2J5; Q7Z5U3; Q7Z674; Q9UHY8
• Molecular Weight: 39,557 Da
• NCBI Official Full Name: fasciculation and elongation protein zeta-2 isoform 2
• NCBI Official Synonym Full Names: fasciculation and elongation protein zeta 2 (zygin II)
• NCBI Official Symbol: FEZ2
• NCBI Official Synonym Symbols: HUM3CL; MGC117372
• NCBI Protein Information: fasciculation and elongation protein zeta-2; zygin 2; zygin-2; zygin II; OTTHUMP00000201286; OTTHUMP00000201287; OTTHUMP00000201289; OTTHUMP00000201293; pre-T/NK cell associated protein (3Cl)
• UniProt Protein Name: Fasciculation and elongation protein zeta 2 (Zygin II)
• Protein Family: Fasciculation and elongation protein
• UniProt Gene Name: FEZ2
• UniProt Entry Name: Q0D2I6_HUMAN

NCBI Description

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. [provided by RefSeq]

Uniprot Description

FEZ2: Involved in axonal outgrowth and fasciculation. Belongs to the zygin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 2p21

Molecular Function: protein binding

Biological Process: axon guidance; nervous system development; signal transduction