Goat anti-Human FasL FasL Polyclonal Antibody | anti-FasL antibody
FasL antibody
Reactivity
Human FasL
Applications
ELISA, Western Blot
Synonyms
FasL; Polyclonal Antibody; FasL antibody; Polyclonal FasL; Anti-FasL; sFASL; APTL; TNFSF6; CD95L; soluble Fas Ligand; Apo I Ligand; anti-FasL antibody
Host
Goat
Reactivity
Human FasL
Clonality
Polyclonal
Specificity
Human FasL
Form/Format
Lyophilized from PBS, pH 7.2.
Sequence Length
277
Applicable Applications for anti-FasL antibody
ELISA (EIA), Inhibition, Western Blot (WB)
Application Notes
ELISA: 0.5-2 ug/ml
Inhibition: 0.08-0.1 ug/ml
WB: 0.1-0.2 ug/ml
Inhibition: 0.08-0.1 ug/ml
WB: 0.1-0.2 ug/ml
Biological Significance
Fas and Fas Ligand (FasL) belong to the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms. These active caspases then cleave various cellular substrates leading to the eventual cell death. sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL.
Immunogen
FasL antibody was raised in goat using highly pure recombinant human FasL/Apo1L as the immunogen.
Preparation and Storage
Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.
Related Product Information for anti-FasL antibody
Affinity purified Goat polyclonal FasL antibody
Product Categories/Family for anti-FasL antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
17.6 kDa (predicted detection band MW)
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 6
NCBI Official Symbol
FASLG
NCBI Protein Information
tumor necrosis factor ligand superfamily member 6
UniProt Protein Name
Fas ligand
UniProt Entry Name
Q9TTJ2_BOVIN
Research Articles on FasL
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Product Notes
The FasL (Catalog #AAA535867) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The FasL antibody reacts with Human FasL and may cross-react with other species as described in the data sheet. AAA Biotech's FasL can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Inhibition, Western Blot (WB). ELISA: 0.5-2 ug/ml Inhibition: 0.08-0.1 ug/ml WB: 0.1-0.2 ug/ml. Researchers should empirically determine the suitability of the FasL for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FasL, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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