Western Blot (WB)
(Western Blot: Sample: Rat Brain Tissue.)
Rabbit anti-Human Excitatory Amino Acid Transporter 3 Polyclonal Antibody | anti-EAAT3 antibody
Polyclonal Antibody to Excitatory Amino Acid Transporter 3 (EAAT3)
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Rat Brain Tissue.)
Western Blot (WB)
(Western Blot: Sample: Rat Brain Tissue.)
Western Blot (WB)
(Western Blot: Sample: Recombinant EAAT3, Human.)
Western Blot (WB)
(Western Blot: Sample: Recombinant EAAT3, Human.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P. Samples: Human Tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P. Samples: Human Tissue))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]
Uniprot Description
SLC1A1: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A1 subfamily.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 9p24.2
Cellular Component: apical plasma membrane; integral component of plasma membrane; membrane; plasma membrane
Molecular Function: amino acid transmembrane transporter activity; chloride transmembrane transporter activity; cysteine transmembrane transporter activity; glutamate binding; glutamate:sodium symporter activity; high-affinity glutamate transmembrane transporter activity; L-glutamate transmembrane transporter activity; metal ion binding; protein binding
Biological Process: cysteine transport; glutamate secretion; ion transport; L-glutamate import; positive regulation of heart rate; protein homooligomerization; synaptic transmission
Disease: Schizophrenia 18
Research Articles on EAAT3
Similar Products
Product Notes
The EAAT3 slc1a1 (Catalog #AAA2026177) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Excitatory Amino Acid Transporter 3 (EAAT3) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Excitatory Amino Acid Transporter 3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.5-2ug/mL Immunohistochemistry: 5-20ug/mL Immunocytochemistry: 5-20ug/mL Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the EAAT3 slc1a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Excitatory Amino Acid Transporter 3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
