Western Blot (WB)
(Anti- Eotaxin Picoband antibody, MBS178131, Western blottingAll lanes: Anti Eotaxin (MBS178131) at 0.5ug/mlWB: HELA Whole Cell Lysate at 40ugPredicted bind size: 11KDObserved bind size: 11KD )
anti-Human Eotaxin Polyclonal Antibody | anti-CCL11 antibody
Anti-Eotaxin Antibody
Western Blot Concentration: 0.1-0.5ug/ml
Western Blot (WB)
(Anti- Eotaxin Picoband antibody, MBS178131, Western blottingAll lanes: Anti Eotaxin (MBS178131) at 0.5ug/mlWB: HELA Whole Cell Lysate at 40ugPredicted bind size: 11KDObserved bind size: 11KD )
Western Blot (WB)
(Anti- Eotaxin Picoband antibody, MBS178131, Western blottingAll lanes: Anti Eotaxin (MBS178131) at 0.5ug/mlWB: HELA Whole Cell Lysate at 40ugPredicted bind size: 11KDObserved bind size: 11KD )
Background: CCL11 (Chemokine (C-C motif) ligand 11), also known as Eotaxin, is a small cytokine belonging to the CC chemokine family. Eotaxin selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of Eotaxin are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which Eotaxin is a ligand include CCR2, CCR3 and CCR5. However, it has been found that eotaxin-1 (CCL11) has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3. The gene for human Eotaxin is encoded on three exons and is located on chromosome 17q12.
NCBI and Uniprot Product Information
NCBI Description
This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]
Uniprot Description
CCL11: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family.
Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: extracellular region; extracellular space; intracellular
Molecular Function: CCR chemokine receptor binding; chemokine activity; protein binding
Biological Process: actin filament organization; cell adhesion; cellular calcium ion homeostasis; chemotaxis; chronic inflammatory response; cytoskeleton organization and biogenesis; eosinophil chemotaxis; G-protein coupled receptor protein signaling pathway; inflammatory response; lymphocyte chemotaxis; mast cell chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of actin filament polymerization; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; positive regulation of inflammatory response; protein amino acid phosphorylation; regulation of cell shape; response to radiation; response to virus; signal transduction
Disease: Asthma, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To
Research Articles on CCL11
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Product Notes
The CCL11 ccl11 (Catalog #AAA178131) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-Eotaxin Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Eotaxin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). ELISA Concentration: 0.1-0.5ug/ml Western Blot Concentration: 0.1-0.5ug/ml. Researchers should empirically determine the suitability of the CCL11 ccl11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Eotaxin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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