Rabbit anti-Human EMR1 / F4/80 Polyclonal Antibody | anti-EMR1 antibody

Rabbit Polyclonal to Human EMR1 / F4/80

Cat. Num. AAA247169

• Gene Names: EMR1; TM7LN3
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: EMR1 / F4/80; Polyclonal Antibody; Rabbit Polyclonal to Human EMR1 / F4/80; Anti-EMR1 / F4/80 Antibody (C-Terminus) IHC-plus; EMR1; EMR1 hormone receptor; F4/80; EGF-like module receptor 1; TM7LN3; Human EMR1; anti-EMR1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Human EMR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 886

• Applicable Applications for anti-EMR1 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (24 - 36 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 18 amino acid peptide from C-terminus of human EMR1. Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Marmoset (89%); Gibbon (83%).
• Immunogen Type: Synthetic peptide
• Immunogen: EMR1 / F4/80 antibody was raised against synthetic 18 amino acid peptide from C-terminus of human EMR1. Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Marmoset (89%); Gibbon (83%).
• Antigen Modification: C-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-EMR1 / F4/80 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-EMR1 / F4/80 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-EMR1 antibody IHC of human bone marrow. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-EMR1 antibody

EGF-Like Module Containing Mucin-Like Hormone Receptor-Like Sequence 1 (EMR1) is characterized as an Orphan-B GPCR with an unknown ligand. The C-terminus contains seven hydrophobic segments, characteristic of a G protein-coupled receptor. The N-terminus of EMR1 has 6 EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties.

Product Categories/Family for anti-EMR1 antibody

Family: GPCR; Subfamily: Orphan-B

NCBI and Uniprot Product Information

• NCBI GI #: 40807489
• NCBI GeneID: 2015
• NCBI Accession #: NP_001965.3
• NCBI GenBank Nucleotide #: NM_001974.4
• UniProt Accession #: Q14246; Q2I7G5; Q6ZMN0; Q8NGA7; A6NHV2; B7Z486; B7Z489; E7EPX9; E9PD45; H9KV79
• Molecular Weight: 82,771 Da
• NCBI Official Full Name: EGF-like module-containing mucin-like hormone receptor-like 1 isoform 1
• NCBI Official Synonym Full Names: egf-like module containing, mucin-like, hormone receptor-like 1
• NCBI Official Symbol: EMR1
• NCBI Official Synonym Symbols: TM7LN3
• NCBI Protein Information: EGF-like module-containing mucin-like hormone receptor-like 1; EMR1 hormone receptor; EGF-like module receptor 1; egf-like module containing, mucin-like, hormone receptor-like sequence 1
• UniProt Protein Name: EGF-like module-containing mucin-like hormone receptor-like 1
• UniProt Gene Name: EMR1
• UniProt Synonym Gene Names: TM7LN3
• UniProt Entry Name: EMR1_HUMAN

NCBI Description

This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Uniprot Description

EMR1: Could be involved in cell-cell interactions. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 2; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: integral to plasma membrane; external side of plasma membrane

Molecular Function: G-protein coupled receptor activity; calcium ion binding

Biological Process: G-protein coupled receptor protein signaling pathway; cell adhesion