Mouse X-Box Binding Protein 1 (XBP1) ELISA Kit | XBP1 elisa kit

Mouse X-Box Binding Protein 1 (XBP1) ELISA Kit

Cat. Num. AAA453711

• Gene Names: Xbp1; TREB5; XBP-1; TREB-5; D11Ertd39e
• Reactivity: Mouse
• Synonyms: X-Box Binding Protein 1 (XBP1); Mouse X-Box Binding Protein 1 (XBP1) ELISA Kit; TREB5; XBP2; Tax-responsive element-binding protein 5; XBP1 elisa kit

• Reactivity: Mouse
• Sequence Length: 371

• Samples: Tissue homogenates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 0.156-10ng/mL
• Sensitivity: 0.061ng/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Standard Curve/Testing Data

NCBI and Uniprot Product Information

• NCBI GI #: 411147451
• NCBI GeneID: 22433
• NCBI Accession #: NP_001258659.1
• NCBI GenBank Nucleotide #: NM_001271730.1
• UniProt Accession #: O35426; Q8VHM0; Q922G5; Q9ESS3
• Molecular Weight: 39,888 Da
• NCBI Official Full Name: X-box-binding protein 1 isoform XBP1(S)
• NCBI Official Synonym Full Names: X-box binding protein 1
• NCBI Official Symbol: Xbp1
• NCBI Official Synonym Symbols: TREB5; XBP-1; TREB-5; D11Ertd39e
• NCBI Protein Information: X-box-binding protein 1
• UniProt Protein Name: X-box-binding protein 1
• Protein Family: X-box-binding protein
• UniProt Gene Name: Xbp1
• UniProt Synonym Gene Names: TREB-5Curated

Uniprot Description

Functions as a transcription factor during endoplasmic reticulum stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development and the development of secretory tissues such as exocrine pancreas and salivary gland (PubMed:10425189, PubMed:10652269, PubMed:16362047, PubMed:17612490). Involved in differentiation of B lymphocytes to plasma cells and production of immunoglobulins. Modulates the cellular response to ER stress in a PIK3R-dependent manner. Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions (PubMed:23529610). Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (PubMed:15486293).