Rabbit DYNLL1 Polyclonal Antibody | anti-DYNLL1 antibody

DYNLL1 Polyclonal Antibody

Cat. Num. AAA2525462

• Gene Names: DYNLL1; LC8; PIN; DLC1; DLC8; LC8a; DNCL1; hdlc1; DNCLC1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: DYNLL1; Polyclonal Antibody; DYNLL1 Polyclonal Antibody; LC8; PIN; DLC1; DLC8; LC8a; DNCL1; hdlc1; DNCLC1; anti-DYNLL1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1.2mg/mL (varies by lot)
• Sequence Length: 89

• Applicable Applications for anti-DYNLL1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:1000-1:5000; IHC: 1:25-1:100
• Immunogen: Recombinant protein of human DYNLL1
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Western Blot (WB)

(Western Blot analysis of Mouse brain tissue using DYNLL1 Polyclonal Antibody at dilution of 1:600)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human prostate cancer using DYNLL1 Polyclonal Antibody at dilution of 1:25)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human brain using DYNLL1 Polyclonal Antibody at dilution of 1:25)

Related Product Information for anti-DYNLL1 antibody

Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1, 200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.

Product Categories/Family for anti-DYNLL1 antibody

Cancer; Cell biology; Epigenetics

NCBI and Uniprot Product Information

• NCBI GI #: 83267868
• NCBI GeneID: 8655
• NCBI Accession #: NP_001032584.1
• NCBI GenBank Nucleotide #: NM_001037495.1
• Molecular Weight: 10,366 Da
• NCBI Official Full Name: dynein light chain 1, cytoplasmic
• NCBI Official Synonym Full Names: dynein, light chain, LC8-type 1
• NCBI Official Symbol: DYNLL1
• NCBI Official Synonym Symbols: LC8; PIN; DLC1; DLC8; LC8a; DNCL1; hdlc1; DNCLC1
• NCBI Protein Information: dynein light chain 1, cytoplasmic; 8 kDa dynein light chain; cytoplasmic dynein light polypeptide; dynein, cytoplasmic, light polypeptide 1; protein inhibitor of neuronal nitric oxide synthase
• UniProt Protein Name: Dynein light chain 1, cytoplasmic
• UniProt Gene Name: DYNLL1
• UniProt Synonym Gene Names: DLC1; DNCL1; DNCLC1; HDLC1; DLC8; PIN
• UniProt Entry Name: DYL1_HUMAN

NCBI Description

Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

LC8: a highly conserved cytoplasmic protein of the dynein light chain family. Cytoplasmic dyneins are large enzyme complexes. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain. Interacts with and inhibits the activity of neuronal nitric oxide synthase (nNOS). A highly conserved protein, showing 92% amino acid similarity with the nematode homolog. Binding of this protein destabilizes the nNOS dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity.

Protein type: Motility/polarity/chemotaxis; Motor; Microtubule-binding

Chromosomal Location of Human Ortholog: 12q24.23

Cellular Component: kinetochore; signalosome; centrosome; microtubule; membrane; cytoplasmic dynein complex; mitochondrion; cytoplasm; plasma membrane; nucleus; cytosol

Molecular Function: protein C-terminus binding; protein domain specific binding; protein binding; protein homodimerization activity; enzyme binding; nitric-oxide synthase regulator activity; motor activity

Biological Process: anatomical structure morphogenesis; transcription, DNA-dependent; viral reproduction; apoptosis; organelle organization and biogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; female gamete generation; microtubule-based process; substantia nigra development; regulation of transcription, DNA-dependent; transport; regulation of catalytic activity; negative regulation of phosphorylation; mitotic cell cycle; G2/M transition of mitotic cell cycle; actin cytoskeleton organization and biogenesis