Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/60.)
Rabbit anti-Human COG1 Polyclonal Antibody | anti-COG1 antibody
COG1 Antibody
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/60.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/60.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/60.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/60.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex. [provided by RefSeq, Jul 2008]
Uniprot Description
COG1: Required for normal Golgi function. Defects in COG1 are the cause of congenital disorder of glycosylation type 2G (CDG2G); also known as CDG-II caused by COG1 deficiency. CDGs are a family of severe inherited diseases caused by a defect in glycoprotein biosynthesis. They are characterized by under-glycosylated serum glycoproteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Clinical features of CDG2G include failure to thrive, generalized hypotonia, growth retardation and mild psychomotor retardation. CDG2G is biochemically characterized by a defect in O-glycosylation as well as N-glycosylation. Belongs to the COG1 family.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 17q25.1
Cellular Component: Golgi membrane; Golgi apparatus; Golgi transport complex
Molecular Function: protein binding
Biological Process: intra-Golgi vesicle-mediated transport; protein transport; Golgi organization and biogenesis
Disease: Congenital Disorder Of Glycosylation, Type Iig
Research Articles on COG1
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Product Notes
The COG1 cog1 (Catalog #AAA9406023) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The COG1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's COG1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1:50-1:200. Researchers should empirically determine the suitability of the COG1 cog1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "COG1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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