Western Blot (WB)
(Western blot detection of DYNLL1 in 3T3,Hela cell lysates using DYNLL1 Rabbit mAb(1:1000 diluted). Predicted band size:10kDa. Observed band size:10kDa.)
Rabbit DYNLL1 Monoclonal Antibody | anti-DYNLL1 antibody
DYNLL1 Rabbit mAb
IHC: 1:20
ICC/IF: 1:20-1:50
FC/FACS: 1:200
IP: 1:20
Western Blot (WB)
(Western blot detection of DYNLL1 in 3T3,Hela cell lysates using DYNLL1 Rabbit mAb(1:1000 diluted). Predicted band size:10kDa. Observed band size:10kDa.)
Western Blot (WB)
(Western blot detection of DYNLL1 in 3T3,Hela cell lysates using DYNLL1 Rabbit mAb(1:1000 diluted). Predicted band size:10kDa. Observed band size:10kDa.)
Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.
NCBI and Uniprot Product Information
NCBI Description
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Description
LC8: a highly conserved cytoplasmic protein of the dynein light chain family. Cytoplasmic dyneins are large enzyme complexes. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain. Interacts with and inhibits the activity of neuronal nitric oxide synthase (nNOS). A highly conserved protein, showing 92% amino acid similarity with the nematode homolog. Binding of this protein destabilizes the nNOS dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity.
Protein type: Motility/polarity/chemotaxis; Motor; Microtubule-binding
Chromosomal Location of Human Ortholog: 12q24.23
Cellular Component: signalosome; kinetochore; microtubule; centrosome; cytoplasmic dynein complex; mitochondrion; membrane; cytoplasm; plasma membrane; cytosol; nucleus
Molecular Function: protein C-terminus binding; protein domain specific binding; protein binding; protein homodimerization activity; enzyme binding; nitric-oxide synthase regulator activity; motor activity
Biological Process: anatomical structure morphogenesis; viral reproduction; transcription, DNA-dependent; apoptosis; organelle organization and biogenesis; female gamete generation; antigen processing and presentation of exogenous peptide antigen via MHC class II; microtubule-based process; substantia nigra development; regulation of transcription, DNA-dependent; regulation of catalytic activity; transport; negative regulation of phosphorylation; mitotic cell cycle; G2/M transition of mitotic cell cycle; actin cytoskeleton organization and biogenesis
Research Articles on DYNLL1
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Product Notes
The DYNLL1 dynll1 (Catalog #AAA4752708) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DYNLL1 Rabbit mAb reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's DYNLL1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FC/FACS), Immunoprecipitation (IP). WB: 1:1000-1:5000 IHC: 1:20 ICC/IF: 1:20-1:50 FC/FACS: 1:200 IP: 1:20. Researchers should empirically determine the suitability of the DYNLL1 dynll1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DYNLL1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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