Western Blot (WB)
(Western Blot: Sample: Lane1: Mouse Liver Tissue; Lane2: Mouse Lung Tissue.)
Rabbit anti-Mouse Xanthine Dehydrogenase Polyclonal Antibody | anti-XDH antibody
Polyclonal Antibody to Xanthine Dehydrogenase (XDH)
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Lane1: Mouse Liver Tissue; Lane2: Mouse Lung Tissue.)
Western Blot (WB)
(Western Blot: Sample: Lane1: Mouse Liver Tissue; Lane2: Mouse Lung Tissue.)
Western Blot (WB)
(Western Blot: Sample: Recombinant XDH, Mouse.)
Western Blot (WB)
(Western Blot: Sample: Recombinant XDH, Mouse.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Stomach Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Stomach Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Large Intestine Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Large Intestine Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Kidney Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Kidney Tissue)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the xanthine dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein exists as two distinct enzymatic forms, either as xanthine dehydrogenase, or as xanthine oxidase, and functions in purine degradation. Additional studies also suggest a role in adipogenesis, and a function as a structural protein in milk fat droplets in the lactating mammary gland. [provided by RefSeq, Jan 2014]
Uniprot Description
XDH: Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). Defects in XDH are the cause of xanthinuria type 1 (XU1). Xanthinuria is characterized by excretion of very large amounts of xanthine in the urine and a tendency to form xanthine stones. Uric acid is strikingly diminished in serum and urine. XU1 is due to isolated xanthine dehydrogenase. XU1 patients can metabolize allopurinol. Belongs to the xanthine dehydrogenase family.
Protein type: EC 1.17.1.4; EC 1.17.3.2; Nucleotide Metabolism - purine; Oxidoreductase; Secondary Metabolites Metabolism - caffeine; Xenobiotic Metabolism - drug metabolism - other enzymes
Chromosomal Location of Human Ortholog: 17 E2|17 45.25 cM
Cellular Component: cytoplasm; cytosol; extracellular region; extracellular space; peroxisome; sarcoplasmic reticulum
Molecular Function: 2 iron, 2 sulfur cluster binding; catalytic activity; electron transfer activity; FAD binding; iron ion binding; iron-sulfur cluster binding; metal ion binding; molybdenum ion binding; molybdopterin cofactor binding; nitrite reductase (NO-forming) activity; oxidoreductase activity; oxidoreductase activity, acting on CH-OH group of donors; oxidoreductase activity, acting on the aldehyde or oxo group of donors; protein binding; protein homodimerization activity; xanthine dehydrogenase activity; xanthine oxidase activity
Biological Process: activation of cysteine-type endopeptidase activity involved in apoptotic process; hypoxanthine oxidation; lactation; negative regulation of endothelial cell differentiation; negative regulation of endothelial cell proliferation; negative regulation of gene expression; negative regulation of protein kinase B signaling cascade; negative regulation of protein phosphorylation; negative regulation of vascular endothelial growth factor signaling pathway; negative regulation of vasculogenesis; positive regulation of p38MAPK cascade; positive regulation of reactive oxygen species metabolic process; regulation of epithelial cell differentiation; response to aluminum ion; xanthine catabolic process
Research Articles on XDH
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Product Notes
The XDH xdh (Catalog #AAA2027652) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Xanthine Dehydrogenase (XDH) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Xanthine Dehydrogenase can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.5-5ug/mL Immunohistochemistry: 5-20ug/mL Immunocytochemistry: 5-20ug/mL Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the XDH xdh for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Xanthine Dehydrogenase, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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