Testing Data
(Mouse kidney tissue were subjected to SDS-PAGE followed by western blot with DOC2B antibody at dilution of 1 :600)
Rabbit DOC2B Polyclonal Antibody | anti-DOC2B antibody
DOC2B Antibody
IF: 1:10-1:100
Testing Data
(Mouse kidney tissue were subjected to SDS-PAGE followed by western blot with DOC2B antibody at dilution of 1 :600)
Testing Data
(Mouse kidney tissue were subjected to SDS-PAGE followed by western blot with DOC2B antibody at dilution of 1 :600)
Immunofluorescent
(Immunofluorescent analysis of HepG2 cells, using DOC2B antibody at 1 :25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).)
Immunofluorescent
(Immunofluorescent analysis of HepG2 cells, using DOC2B antibody at 1 :25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).)
NCBI and Uniprot Product Information
NCBI Description
There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells. [provided by RefSeq, Jul 2008]
Uniprot Description
DOC2B: Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes.
Protein type: Lipid-binding
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component: SNARE complex; synaptic vesicle; cytoplasm; plasma membrane
Molecular Function: calcium-dependent phospholipid binding; transporter activity
Biological Process: positive regulation of calcium ion-dependent exocytosis; protein localization; calcium ion-dependent exocytosis of neurotransmitter; positive regulation of insulin secretion; positive regulation of vesicle fusion
Research Articles on DOC2B
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Product Notes
The DOC2B doc2b (Catalog #AAA2522933) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DOC2B Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's DOC2B can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunofluorescence (IF). WB: 1:200-1:2000 IF: 1:10-1:100. Researchers should empirically determine the suitability of the DOC2B doc2b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DOC2B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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