Rabbit anti-Human DISP2 Polyclonal Antibody | anti-DISP2 antibody

DISP2 Antibody

Cat. Num. AAA151414

• Gene Names: DISP2; DISPB; HsT16908
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: DISP2 Antibody is affinity chromatography purified via peptide column.
• Synonyms: DISP2; Polyclonal Antibody; DISP2 Antibody; DISPB; HsT16908; KIAA1742; Protein dispatched homolog 2; dispatched homolog 2 (Drosophila); anti-DISP2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: DISP2 antibody is human specific. At least two isoforms of Disp2 are known to exist. DISP2 antibody is predicted to not cross-react with Disp1 or Disp3.
• Purity/Purification: DISP2 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 1401

• Applicable Applications for anti-DISP2 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: DISP2 antibody can be used for detection of DISP2 by immunohistochemistry at 5 mug/mL.
• Conjugate: Unconjugated
• Immunogen: DISP2 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human DISP2.
• Buffer: DISP2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: DISP2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Immunohistochemistry (IHC)

(Immunohistochemistry of DISP2 in human small intestine tissue with DISP2 antibody at 5 μg/mL.)

Related Product Information for anti-DISP2 antibody

DISP2 Antibody: DISP2 is the second of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants.

NCBI and Uniprot Product Information

• NCBI GI #: 160380692
• NCBI GeneID: 85455
• UniProt Accession #: A7MBM2; Q6AHW3; Q9C0C1
• Molecular Weight: 152,003 Da
• NCBI Official Full Name: Protein dispatched homolog 2
• NCBI Official Synonym Full Names: dispatched homolog 2 (Drosophila)
• NCBI Official Symbol: DISP2
• NCBI Official Synonym Symbols: DISPB; HsT16908
• NCBI Protein Information: protein dispatched homolog 2; dispatched B
• UniProt Protein Name: Protein dispatched homolog 2
• Protein Family: Protein dispatched
• UniProt Gene Name: DISP2
• UniProt Synonym Gene Names: DISPB; KIAA1742
• UniProt Entry Name: DISP2_HUMAN

NCBI Description

The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched. [provided by RefSeq, Jul 2008]

Uniprot Description

DISP2: The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched. [provided by RefSeq, Jul 2008]

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: integral to membrane; plasma membrane

Biological Process: smoothened signaling pathway