Rabbit anti-Human IRF2BP2 Polyclonal Antibody | anti-IRF2BP2 antibody

IRF2BP2 Antibody

Cat. Num. AAA151577

• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: IRF2BP2 Antibody is affinity chromatography purified via peptide column.
• Synonyms: IRF2BP2; Polyclonal Antibody; IRF2BP2 Antibody; Interferon regulatory factor 2-binding protein 2; IRF-2-binding protein 2; interferon regulatory factor 2 binding protein 2; anti-IRF2BP2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: At least two isoforms of IRF2BP2 are known to exist; this antibody will detect both.
• Purity/Purification: IRF2BP2 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 587

• Applicable Applications for anti-IRF2BP2 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IRF2BP2 antibody can be used for detection of IRF2BP2 by immunohistochemistry at 5 mug/mL.
• Conjugate: Unconjugated
• Immunogen: IRF2BP2 antibody was raised against an 17 amino acid synthetic peptide near the amino terminus of human IRF2BP2.
• Buffer: IRF2BP2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: IRF2BP2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Immunohistochemistry (IHC)

(Immunohistochemistry of IRF2BP2 in human placenta with IRF2BP2 antibody at 5 μg/mL.)

Related Product Information for anti-IRF2BP2 antibody

IRF2BP2 Antibody: IRF2BP2, like the related protein IRF2BP1, is a co-repressor that interacts specifically with the C-terminal repression domain of Interferon Regulatory Factor 2 (IRF2). IRF2BP2 is a direct target gene of p53 and is involved in cell survival during the p53 stress response, able to impede the p53-mediated transactivation of p21 and Bax. IRF2BP2 is also a co-factor of VGLL4 and is required to induce the expression of vascular endothelial growth factor A (VEGF-A) in muscle. It is normally found in the nucleus of skeletal muscle and cardiac cells, but can be found in the cytoplasm during skeletal muscle differentiation.

NCBI and Uniprot Product Information

• NCBI GI #: 116734704
• NCBI GeneID: 359948
• NCBI Accession #: NP_892017
• NCBI GenBank Nucleotide #: NM_182972.2
• UniProt Accession #: Q7Z5L9; Q6P083; Q7Z5L8; Q8N351; Q8WUH8; B1AM35; B1AM36
• Molecular Weight: 17,139 Da
• NCBI Official Full Name: interferon regulatory factor 2-binding protein 2 isoform A
• NCBI Official Synonym Full Names: interferon regulatory factor 2 binding protein 2
• NCBI Official Symbol: IRF2BP2
• NCBI Protein Information: interferon regulatory factor 2-binding protein 2; IRF-2-binding protein 2
• UniProt Protein Name: Interferon regulatory factor 2-binding protein 2
• Protein Family: Interferon regulatory factor 2-binding protein
• UniProt Gene Name: IRF2BP2
• UniProt Synonym Gene Names: IRF-2-binding protein 2; IRF-2BP2
• UniProt Entry Name: I2BP2_HUMAN

NCBI Description

This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

IRF2BP2: Acts as a transcriptional corepressor in a IRF2- dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle. Belongs to the IRF2BP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 1q42.3

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: metal ion binding

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent