Immunohistochemistry (IHC)
(Immunohistochemistry of PTCHD2 in human testis tissue with PTCHD2 antibody at 5 ug/mL.)
Rabbit anti-Human PTCHD2 Polyclonal Antibody | anti-PTCHD2 antibody
PTCHD2 Antibody
Gene Names
PTCHD2; DISP3
Reactivity
Human
Applications
ELISA, Immunohistochemistry
Purity
Affinity chromatography purified via peptide column
Synonyms
PTCHD2; Polyclonal Antibody; PTCHD2 Antibody; Patched domain-containing protein 2; DISP3; anti-PTCHD2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
At least two isoforms of PTCHD2 are known to exist. This antibody is specific for PTCHD2 and will not recognize the other DISP family of proteins.
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
1392
Applicable Applications for anti-PTCHD2 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Immunogen Type
Peptide
Immunogen Description
Raised against a 14 amino acid peptide from near the carboxy terminus of human PTCHD2.
Target Name
PTCHD2
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Immunohistochemistry (IHC)
(Immunohistochemistry of PTCHD2 in human testis tissue with PTCHD2 antibody at 5 ug/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of PTCHD2 in human testis tissue with PTCHD2 antibody at 5 ug/mL.)
Related Product Information for anti-PTCHD2 antibody
PTCHD2, also known as DISP3, is the third of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored secreted proteins. Like DISP1 and DISP2, DISP3 has been implicated in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis. It is highly expressed in Purkinje cells, hippocampal neurons, and retinal ganglion cells. Recently, it has been shown that PTCHD2 localizes within the endoplasmic reticulum and colocalizes with cholesterol, and given that its expression is regulated by thyroid hormone (T3), it has been suggested that DISP3 may be a link between thyroid hormone and cholesterol metabolism.
Product Categories/Family for anti-PTCHD2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
103,766 Da
NCBI Official Full Name
patched domain-containing protein 2
NCBI Official Synonym Full Names
patched domain containing 2
NCBI Official Symbol
PTCHD2
NCBI Official Synonym Symbols
DISP3
NCBI Protein Information
patched domain-containing protein 2
UniProt Protein Name
Patched domain-containing protein 2
UniProt Gene Name
PTCHD2
UniProt Synonym Gene Names
DISP3; KIAA1337
UniProt Entry Name
PTHD2_HUMAN
Uniprot Description
PTCHD2: Belongs to the patched family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1p36.22
Cellular Component: nuclear membrane; endoplasmic reticulum; integral to membrane
Molecular Function: hedgehog receptor activity
Biological Process: cholesterol homeostasis; smoothened signaling pathway; regulation of lipid transport
Research Articles on PTCHD2
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Product Notes
The PTCHD2 ptchd2 (Catalog #AAA9407915) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PTCHD2 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PTCHD2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the PTCHD2 ptchd2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PTCHD2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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