Immunohistochemistry (IHC)
(Immunochemical staining of mouse PTPRJ in mouse brain with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)
Rabbit DEP-1 Polyclonal Antibody | anti-PTPRJ antibody
Anti-DEP-1 Antibody, Rabbit Polyclonal
Gene Names
Ptprj; BET; Byp; Scc1; CD148; DEP-1; Ptpb2; RPTPJ; Scc-1; AI450271; PTPbeta2
Reactivity
MousePredicted to React with: Human (Species predicted to react based on 100% sequence homology)
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
DEP-1; Polyclonal Antibody; Anti-DEP-1 Antibody; Rabbit Polyclonal; DEP1/PTPRJ Antibody; Rabbit PAb; Antigen Affinity Purified; protein tyrosine phosphatase; receptor type; J; Anti-AI450271 Antibody; Anti-BET Antibody; Anti-Byp Antibody; Anti-CD148 Antibody; Anti-Ptpb2 Antibody; Anti-PTPbeta2 Antibody; Anti-RPTPJ Antibody; Anti-Scc-1 Antibody; Anti-Scc1 Antibody; anti-PTPRJ antibody
Host
Rabbit
Reactivity
Mouse
Predicted to React with: Human (Species predicted to react based on 100% sequence homology)
Predicted to React with: Human (Species predicted to react based on 100% sequence homology)
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Mouse DEP-1
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-PTPRJ antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:500-1:2000
Immunogen
A synthetic peptide corresponding to the C-terminus of the Mouse DEP1/PTPRJ
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Mouse DEP1/PTPRJ, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of mouse PTPRJ in mouse brain with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)
Immunohistochemistry (IHC)
(Immunochemical staining of mouse PTPRJ in mouse brain with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)
Related Product Information for anti-PTPRJ antibody
DEP1/PTPRJ (Receptor-type tyrosine-protein phosphatase eta) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. DEP1/PTPRJ possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. DEP1/PTPRJ is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. In stable MCF-7 cell lines, induction of DEP-1 expression inhibited breast cancer cell growth by 5-10-fold. These data describe PTPs expressed and regulated in breast cancer cell lines during differentiation and identify one PTP, DEP-1, that inhibits the growth of breast cancer cells in vitro.
Product Categories/Family for anti-PTPRJ antibody
References
Holsinger LJ, et al. (2002) The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120. Oncogene. 21(46): 7067-76.Huang X, et al. (2009) Natural variation at the DEP1 locus enhances grain yield in rice. Nat Genet. 41(4): 494-7.Kuramochi S, et al. (1996) Molecular cloning and characterization of Byp, a murine receptor-type tyrosine phosphatase similar to human DEP-1. FEBS Lett. 378(1): 7-14.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
136,769 Da
NCBI Official Full Name
receptor-type tyrosine-protein phosphatase eta isoform 1
NCBI Official Synonym Full Names
protein tyrosine phosphatase, receptor type, J
NCBI Official Symbol
Ptprj
NCBI Official Synonym Symbols
BET; Byp; Scc1; CD148; DEP-1; Ptpb2; RPTPJ; Scc-1; AI450271; PTPbeta2
NCBI Protein Information
receptor-type tyrosine-protein phosphatase eta; R-PTP-J; R-PTP-eta; colon tumor susceptibility 1; protein-tyrosine phosphatase eta; susceptibility to colon cancer 1; HPTP beta-like tyrosine phosphatase; protein-tyrosine phosphatase receptor type J
UniProt Protein Name
Receptor-type tyrosine-protein phosphatase eta
Protein Family
UniProt Gene Name
Ptprj
UniProt Synonym Gene Names
Byp; Scc1; Protein-tyrosine phosphatase eta; R-PTP-eta; R-PTP-J
UniProt Entry Name
PTPRJ_MOUSE
Similar Products
Product Notes
The PTPRJ ptprj (Catalog #AAA8101914) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-DEP-1 Antibody, Rabbit Polyclonal reacts with Mouse Predicted to React with: Human (Species predicted to react based on 100% sequence homology) and may cross-react with other species as described in the data sheet. AAA Biotech's DEP-1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:500-1:2000. Researchers should empirically determine the suitability of the PTPRJ ptprj for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DEP-1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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