Rabbit DEP1 Polyclonal Antibody | anti-DEP1 antibody

DEP1 Polyclonal Antibody

Cat. Num. AAA3013892

• Gene Names: PTPRJ; DEP1; SCC1; CD148; HPTPeta; R-PTP-ETA
• Reactivity: Human, Mouse, Rat, Rabbit
• Applications: Western Blot
• Purity: affinity purified by Protein A
• Synonyms: DEP1; Polyclonal Antibody; DEP1 Polyclonal Antibody; CD 148; CD148; CD148 antigen; Density enhanced phosphatase 1; Density-enhanced phosphatase 1; DEP 1; DEP-1; HPTP eta; HPTPeta; Human density enhanced phosphatase 1; Protein tyrosine phosphatase eta; Protein tyrosine phosphatase receptor type J; Protein tyrosine phosphatase receptor type J polypeptide; Protein-tyrosine phosphatase eta; Protein-tyrosine phosphatase receptor type J; PTPJ; Ptprj; PTPRJ_HUMAN; R PTP Eta; R-PTP-eta; R-PTP-J; Receptor type tyrosine protein phosphatase eta; Receptor-type tyrosine-protein phosphatase eta; SCC 1; SCC1. ; anti-DEP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat, Rabbit
• Clonality: Polyclonal
• Specificity: DEP1 Polyclonal Antibody detects endogenous levels of DEP1 protein.
• Purity/Purification: affinity purified by Protein A
• Form/Format: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Applicable Applications for anti-DEP1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-2000
• Immunogen: KLH conjugated synthetic peptide derived from human PTPRJ:865-970/1337
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Testing Data

(Sample: Lymph node (Mouse) Lysate at 40 ug Thymus (Mouse) Lysate at 40 ug Primary: Anti-DEP1 at 1/1000 dilution)

Testing Data

(Sample: Hela(Human) Cell Lysate at 30 ug Jurkat(Human) Cell Lysate at 30 ug K562(Human) Cell Lysate at 30 ug Raji(Human) Cell Lysate at 30 ug Primary: Anti-DEP1 at 1/1000 dilution)

Related Product Information for anti-DEP1 antibody

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

NCBI and Uniprot Product Information

• NCBI GI #: 39645413
• NCBI GeneID: 5795
• UniProt Accession #: Q12913; Q15255; Q6P4H4; Q8NHM2; Q9UDA9
• Molecular Weight: 57,190 Da
• NCBI Official Full Name: PTPRJ protein
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, receptor type J
• NCBI Official Symbol: PTPRJ
• NCBI Official Synonym Symbols: DEP1; SCC1; CD148; HPTPeta; R-PTP-ETA
• NCBI Protein Information: receptor-type tyrosine-protein phosphatase eta
• UniProt Protein Name: Receptor-type tyrosine-protein phosphatase eta
• Protein Family: Transcriptional regulatory protein
• UniProt Gene Name: PTPRJ
• UniProt Synonym Gene Names: DEP1; Protein-tyrosine phosphatase eta; R-PTP-eta; DEP-1; R-PTP-J

NCBI Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.