Immunohistochemistry (IHC)
(Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit DCK / Deoxycytidine kinase Polyclonal Antibody | anti-DCK antibody
Anti-DCK / Deoxycytidine kinase Antibody IHC-plus
IHC-P (5 ug/ml)
WB (1:500 - 1:2000)
Short term: -20 degree C
Avoid freeze-thaw cycles.
Immunohistochemistry (IHC)
(Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE))
Immunohistochemistry (IHC)
(Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE))
Immunofluorescence (IF)
(Immunofluorescence analysis of MCF7 cell using DCK antibody. Blue: DAPI for nuclear staining.)
Immunofluorescence (IF)
(Immunofluorescence analysis of MCF7 cell using DCK antibody. Blue: DAPI for nuclear staining.)
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using DCK antibody.)
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using DCK antibody.)
NCBI and Uniprot Product Information
NCBI Description
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]
Uniprot Description
DCK: Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. Belongs to the DCK/DGK family.
Protein type: Nucleotide Metabolism - purine; Kinase, other; EC 2.7.1.74; Nucleotide Metabolism - pyrimidine
Chromosomal Location of Human Ortholog: 4q13.3-q21.1
Cellular Component: cytosol; nucleus
Molecular Function: ATP binding; deoxycytidine kinase activity; drug binding; nucleoside kinase activity; protein homodimerization activity
Biological Process: deoxyribonucleoside monophosphate biosynthetic process; nucleobase, nucleoside and nucleotide metabolic process; nucleotide biosynthetic process; phosphorylation; purine base metabolic process; purine salvage; pyrimidine base metabolic process; pyrimidine nucleoside salvage; pyrimidine nucleotide metabolic process
Research Articles on DCK
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Product Notes
The DCK dck (Catalog #AAA249732) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-DCK / Deoxycytidine kinase Antibody IHC-plus reacts with Mouse, Rat, Human and may cross-react with other species as described in the data sheet. AAA Biotech's DCK / Deoxycytidine kinase can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), Western Blot (WB). IF (1:50 - 1:200) IHC-P (5 ug/ml) WB (1:500 - 1:2000). Researchers should empirically determine the suitability of the DCK dck for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DCK / Deoxycytidine kinase, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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