Mouse anti-Human DCK Monoclonal Antibody | anti-DCK antibody

Mouse monoclonal antibody Anti-Human DCK

Cat. Num. AAA120196

• Reactivity: Human
• Applications: Dot Blot
• Synonyms: DCK; Monoclonal Antibody; Mouse monoclonal antibody Anti-Human DCK; Homo sapiens deoxycytidine kinase (DCK); mRNA; MGC117410;MGC138632; anti-DCK antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 2243C2
• Concentration: 100 ug/ml (1.0 ml) (varies by lot)
• Sequence Length: 2618

• Applicable Applications for anti-DCK antibody: Dot Blot (DB)
• Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
• Sterility: Filtered through a 0.22 um membrane.

Quality Control

(Western blot analysis of immunized recombinant protein, using anti-DCK monoclonal antibody. )

Quality Control #2

(Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.)

Related Product Information for anti-DCK antibody

Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [NCBI Entrez Gene Summary]

NCBI and Uniprot Product Information

• NCBI GI #: 194578889
• NCBI GeneID: 1633
• NCBI Accession #: NP_000779.1
• NCBI GenBank Nucleotide #: NM_000788
• Molecular Weight: 30,519 Da
• NCBI Official Full Name: Homo sapiens deoxycytidine kinase (DCK), mRNA
• NCBI Official Synonym Full Names: deoxycytidine kinase
• NCBI Official Symbol: DCK
• NCBI Protein Information: deoxycytidine kinase; deoxynucleoside kinase
• UniProt Protein Name: Deoxycytidine kinase
• Protein Family: Deoxycytidine kinase
• UniProt Gene Name: DCK
• UniProt Entry Name: DCK_HUMAN

NCBI Description

Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]

Uniprot Description

DCK: Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. Belongs to the DCK/DGK family.

Protein type: Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Kinase, other; EC 2.7.1.74

Chromosomal Location of Human Ortholog: 4q13.3-q21.1

Cellular Component: nucleus; cytosol

Molecular Function: protein homodimerization activity; nucleoside kinase activity; deoxycytidine kinase activity; drug binding; ATP binding

Biological Process: pyrimidine base metabolic process; pyrimidine nucleotide metabolic process; nucleotide biosynthetic process; nucleobase, nucleoside and nucleotide metabolic process; pyrimidine nucleoside salvage; phosphorylation; purine salvage; purine base metabolic process; deoxyribonucleoside monophosphate biosynthetic process