Western Blot (WB)
(Western blot analysis of GSK3 beta expression in mouse brain (A), mouse heart (B), rat brain (C), rat heart (D) whole cell lysates.)
Rabbit anti-Mouse, Rat Cyclin D1 Polyclonal Antibody | anti-CCND1 antibody
Anti-Cyclin D1 Antibody
Western Blot (WB)
(Western blot analysis of GSK3 beta expression in mouse brain (A), mouse heart (B), rat brain (C), rat heart (D) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of GSK3 beta expression in mouse brain (A), mouse heart (B), rat brain (C), rat heart (D) whole cell lysates.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of GSK3 beta staining in mouse lung formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of GSK3 beta staining in mouse lung formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
NCBI and Uniprot Product Information
Uniprot Description
CCND1: a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb.
Protein type: Activator; Cell cycle regulation; Nuclear receptor co-regulator; Oncoprotein
Cellular Component: cyclin-dependent protein kinase holoenzyme complex; cytoplasm; intracellular; membrane; nucleoplasm; nucleus; tight junction; transcriptional repressor complex
Molecular Function: cyclin-dependent protein kinase regulator activity; enzyme binding; histone deacetylase binding; kinase activity; protein binding; protein complex binding; protein kinase activity; protein kinase binding; transcription corepressor activity; transcription factor binding
Biological Process: cell cycle; cell division; fat cell differentiation; G1 DNA damage checkpoint; G1/S transition of mitotic cell cycle; lactation; Leydig cell differentiation; mammary gland epithelial cell proliferation; negative regulation of epithelial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of Wnt receptor signaling pathway; positive regulation of cell proliferation; positive regulation of cyclin-dependent protein kinase activity; positive regulation of mammary gland epithelial cell proliferation; positive regulation of protein amino acid phosphorylation; protein amino acid phosphorylation; re-entry into mitotic cell cycle; regulation of cell cycle; regulation of transcription, DNA-dependent; response to DNA damage stimulus; response to organic nitrogen; transcription, DNA-dependent; unfolded protein response; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin
Research Articles on CCND1
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Product Notes
The CCND1 ccnd1 (Catalog #AAA8243077) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Cyclin D1 Antibody reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Cyclin D1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western Blot: (1/500 - 1/1000); Immunohistochemistry: (1/50 - 1/200). Researchers should empirically determine the suitability of the CCND1 ccnd1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cyclin D1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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