Rabbit Cullin 5 Polyclonal Antibody | anti-CUL5 antibody
Cullin 5 antibody
Gene Names
CUL5; VACM1; VACM-1
Applications
Western Blot
Purity
Cullin 5 antibody was purified by antigen-affinity chromatography
Synonyms
Cullin 5; Polyclonal Antibody; Cullin 5 antibody; Polyclonal Cullin 5; Anti-Cullin 5; vasopressin-activated calcium-mobilizing receptor 1; cullin-5; Cullin -5; Vasopressin-activated calcium-mobilizing receptor-1; CUL5; CUL-5; VACM1; VACM-1; anti-CUL5 antibody
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Cullin 5 antibody was purified by antigen-affinity chromatography
Form/Format
Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative.
Concentration
0.7 mg/ml (varies by lot)
Sequence Length
780
Applicable Applications for anti-CUL5 antibody
Western Blot (WB)
Biological Significance
Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2.
Cross-Reactivity
Human
Immunogen
Cullin 5 antibody was raised in rabbit using a recombinant fragment corresponding to a region within amino acids 113 and 583 of Cullin 5
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Related Product Information for anti-CUL5 antibody
Affinity purified Rabbit polyclonal Cullin 5 antibody
Product Categories/Family for anti-CUL5 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
91 kDa
NCBI Official Full Name
cullin 5
NCBI Official Synonym Full Names
cullin 5
NCBI Official Symbol
CUL5
NCBI Official Synonym Symbols
VACM1; VACM-1
NCBI Protein Information
cullin-5
UniProt Protein Name
Cullin-5
Protein Family
UniProt Gene Name
CUL5
UniProt Synonym Gene Names
VACM1; CUL-5; VACM-1
UniProt Entry Name
CUL5_HUMAN
Uniprot Description
CUL5: a component of E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to be involved proteasomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. Member of the cullin family.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 11q22.3
Cellular Component: Cul5-RING ubiquitin ligase complex; plasma membrane; nucleus; cytosol
Molecular Function: protein binding; protein heterodimerization activity; calcium channel activity; ubiquitin protein ligase binding; receptor activity
Biological Process: ubiquitin-dependent protein catabolic process; negative regulation of cell proliferation; cell proliferation; cytosolic calcium ion homeostasis; viral reproduction; protein ubiquitination; response to osmotic stress; cell cycle arrest; G1/S transition of mitotic cell cycle
Research Articles on CUL5
Similar Products
Product Notes
The CUL5 cul5 (Catalog #AAA837574) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Cullin 5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the CUL5 cul5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cullin 5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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