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Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human tonsil using MBS1495479at dilution 1:100)

Rabbit anti-Human Cullin-5 Polyclonal Antibody | anti-CUL5 antibody

Rabbit anti-human Cullin-5 polyclonal Antibody(CUL5)

Gene Names
CUL5; VACM1; VACM-1
Reactivity
Human
Applications
ELISA, Immunohistochemistry
Purity
Antigen Affinity Purified
Synonyms
Cullin-5; Polyclonal Antibody; Rabbit anti-human Cullin-5 polyclonal Antibody(CUL5); CUL-5; Vasopressin-activated calcium-mobilizing receptor 1; VACM-1; CUL5; VACM1; anti-CUL5 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen Affinity Purified
Sequence Length
780
Applicable Applications for anti-CUL5 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes
Recommended dilution: IHC:1:20-1:200
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Cullin-5 protein(1-300aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-12371 / sc-5325 / sc-13014
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human tonsil using MBS1495479at dilution 1:100)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human tonsil using MBS1495479at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human kidney using MBS1495479at dilution 1:100)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human kidney using MBS1495479at dilution 1:100)
Related Product Information for anti-CUL5 antibody
Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
90,955 Da
NCBI Official Full Name
cullin-5
NCBI Official Synonym Full Names
cullin 5
NCBI Official Symbol
CUL5
NCBI Official Synonym Symbols
VACM1; VACM-1
NCBI Protein Information
cullin-5
UniProt Protein Name
Cullin-5
Protein Family
UniProt Gene Name
CUL5
UniProt Synonym Gene Names
VACM1; CUL-5; VACM-1
UniProt Entry Name
CUL5_HUMAN

Uniprot Description

CUL5: a component of E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to be involved proteasomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. Member of the cullin family.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: Cul5-RING ubiquitin ligase complex; cytosol

Molecular Function: calcium channel activity; protein binding; protein heterodimerization activity; receptor activity; ubiquitin protein ligase binding

Biological Process: cell cycle arrest; cell proliferation; cerebral cortex radially oriented cell migration; G1/S transition of mitotic cell cycle; negative regulation of cell proliferation; protein ubiquitination during ubiquitin-dependent protein catabolic process; radial glia guided migration of Purkinje cell; viral reproduction

Research Articles on CUL5

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Product Notes

The CUL5 cul5 (Catalog #AAA1495479) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Cullin-5 polyclonal Antibody(CUL5) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Cullin-5 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Recommended dilution: IHC:1:20-1:200. Researchers should empirically determine the suitability of the CUL5 cul5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cullin-5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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