Rabbit anti-Human COG8 Polyclonal Antibody | anti-COG8 antibody

COG8 Polyclonal Antibody

Cat. Num. AAA9432124

• Gene Names: COG8; DOR1; CDG2H
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity purification
• Synonyms: COG8; Polyclonal Antibody; COG8 Polyclonal Antibody; CDG2H; DOR1; component of oligomeric golgi complex 8; anti-COG8 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 50% glycerol, pH7.4

• Applicable Applications for anti-COG8 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant fusion protein of human COG8 (NP_115758.3).
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using COG8 antibody.)

Related Product Information for anti-COG8 antibody

This gene encodes a protein that is a component of the conserved oligomeric Golgi (COG) complex, a multiprotein complex that plays a structural role in the Golgi apparatus, and is involved in intracellular membrane trafficking and glycoprotein modification. Mutations in this gene cause congenital disorder of glycosylation, type IIh, a disease that is characterized by under-glycosylated serum proteins, and whose symptoms include severe psychomotor retardation, failure to thrive, seizures, and dairy and wheat product intolerance.

Product Categories/Family for anti-COG8 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 186928841
• NCBI GeneID: 84342
• NCBI Accession #: NP_115758.3
• NCBI GenBank Nucleotide #: NM_032382.4
• UniProt Accession #: Q96MW5; Q0VAK2; Q8WVV6; Q9H6F8
• Molecular Weight: 68,424 Da
• NCBI Official Full Name: conserved oligomeric Golgi complex subunit 8
• NCBI Official Synonym Full Names: component of oligomeric golgi complex 8
• NCBI Official Symbol: COG8
• NCBI Official Synonym Symbols: DOR1; CDG2H
• NCBI Protein Information: conserved oligomeric Golgi complex subunit 8
• UniProt Protein Name: Conserved oligomeric Golgi complex subunit 8
• Protein Family: Conserved oligomeric Golgi complex
• UniProt Gene Name: COG8
• UniProt Synonym Gene Names: COG complex subunit 8
• UniProt Entry Name: COG8_HUMAN

NCBI Description

This gene encodes a protein that is a component of the conserved oligomeric Golgi (COG) complex, a multiprotein complex that plays a structural role in the Golgi apparatus, and is involved in intracellular membrane trafficking and glycoprotein modification. Mutations in this gene cause congenital disorder of glycosylation, type IIh, a disease that is characterized by under-glycosylated serum proteins, and whose symptoms include severe psychomotor retardation, failure to thrive, seizures, and dairy and wheat product intolerance. [provided by RefSeq, Jul 2008]

Uniprot Description

COG8: Required for normal Golgi function. Defects in COG8 are the cause of congenital disorder of glycosylation type 2H (CDG2H). CDGs are a family of severe inherited diseases caused by a defect in protein N- glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Belongs to the COG8 family.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: Golgi membrane; Golgi transport complex; membrane

Molecular Function: protein binding

Biological Process: cellular protein metabolic process; ER to Golgi vesicle-mediated transport; intra-Golgi vesicle-mediated transport; post-translational protein modification; protein amino acid N-linked glycosylation via asparagine; protein transport

Disease: Congenital Disorder Of Glycosylation, Type Iih