Western Blot (WB)
(All lanes: Clusterin antibody at 2ug/ml+293T whole cell lysate)
Rabbit anti-Human Clusterin Polyclonal Antibody | anti-CLU antibody
Clusterin Polyclonal Antibody
Immunohistochemistry: 1:20 - 1:200
Western Blot (WB)
(All lanes: Clusterin antibody at 2ug/ml+293T whole cell lysate)
Western Blot (WB)
(All lanes: Clusterin antibody at 2ug/ml+293T whole cell lysate)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embeded human prostate using at dilution of 1:100.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embeded human prostate using at dilution of 1:100.)
NCBI and Uniprot Product Information
Uniprot Description
CLU: Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress- induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation. Belongs to the clusterin family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Mitochondrial; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 8p21-p12
Cellular Component: cell surface; cytoplasm; extracellular matrix; extracellular region; extracellular space; Golgi apparatus; mitochondrion; perinuclear region of cytoplasm; protein complex
Molecular Function: ATPase activity; chaperone binding; misfolded protein binding; protein binding; ubiquitin protein ligase binding
Biological Process: activation of NF-kappaB transcription factor; cell morphogenesis; chaperone-mediated protein complex assembly; complement activation; microglial cell activation; myelin maintenance in the central nervous system; negative regulation of protein homooligomerization; platelet degranulation; positive regulation of nitric oxide biosynthetic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of tumor necrosis factor production; protein import; protein stabilization; release of cytochrome c from mitochondria; response to misfolded protein; response to virus; reverse cholesterol transport
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Product Notes
The CLU clu (Catalog #AAA9415950) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Clusterin Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Clusterin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western Blot: 1:500 - 1:1000 Immunohistochemistry: 1:20 - 1:200. Researchers should empirically determine the suitability of the CLU clu for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Clusterin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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