Testing Data
Persephin Active Protein | Pspn active protein
Murine Persephin
Gene Names
Pspn; PSP
Reactivity
Species Reactivity: MouseCross Reactivity: Human
Purity
Above 98% as determined by SDS-PAGE Analysis.
Synonyms
Persephin; Murine Persephin; Recombinant Murine Persephin; Pspn active protein
Host
E Coli
Reactivity
Species Reactivity: Mouse
Cross Reactivity: Human
Cross Reactivity: Human
Purity/Purification
Above 98% as determined by SDS-PAGE Analysis.
Sequence
ALAGSCRLW SLTLPVAEL GLGYASEEK VIFRYCAGS CPQEARTQH SLVLARLRG RGRAHGRPC CQPTSYADV TFLDDQHHW QQLPQLSAA ACGCGG
Biological Activity
The ED50 was determined by its ability to stimulate proliferation of human thyroid carcinoma cells (TT cells) is < 0.1 ng/ml, corresponding to a specific activity of > 1 x 107
Cell Type
Neurons
Preparation and Storage
At -20 degree C
Testing Data
Testing Data
Related Product Information for Pspn active protein
Persephin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, Artemin, and Neurturin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Persephin signals through a multicomponent receptor system, composed of RET and one of four GFR alpha (alpha 1- alpha 4) receptors. The GFR alpha 4 was first identified in chicken and was later shown to be the preferential binding subunit for Persephin. Persephin promotes the survival of ventral midbrain dompaminergic neurons and motor neurons after sciatic nerve oxotomy, and like GNDF, promotes ureteric bud branching. However, in contrast to GDNF and Neurturin, Persephin does not support survival of peripheral neurons. Recombinant murine Persephin is a disulfide-linked homodimer, composed of two 10.3 kDa polypeptide chains (96 total amino acid residues). Each chain contains seven conserved cysteine residues, one of which (Cys 63) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration
Product Categories/Family for Pspn active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
17,031 Da
NCBI Official Full Name
Persephin
NCBI Official Synonym Full Names
persephin
NCBI Official Symbol
Pspn
NCBI Official Synonym Symbols
PSP
NCBI Protein Information
persephin
UniProt Protein Name
Persephin
Protein Family
UniProt Gene Name
Pspn
UniProt Synonym Gene Names
PSP
UniProt Entry Name
PSPN_MOUSE
Uniprot Description
PSPN: Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons. Belongs to the TGF-beta family. GDNF subfamily.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: extracellular space; extracellular region
Molecular Function: growth factor activity; receptor binding
Biological Process: ureteric bud branching
Research Articles on Pspn
Similar Products
Product Notes
The Pspn pspn (Catalog #AAA695755) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Murine Persephin reacts with Species Reactivity: Mouse Cross Reactivity: Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: ALAGSCRLW SLTLPVAEL GLGYASEEK VIFRYCAGS CPQEARTQH SLVLARLRG RGRAHGRPC CQPTSYADV TFLDDQHHW QQLPQLSAA ACGCGG. It is sometimes possible for the material contained within the vial of "Persephin, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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