Western Blot (WB)
(Western blot analysis of CLDN8 Antibody (Center) in 293 cell line lysates (35ug/lane). CLDN8 (arrow) was detected using the purified Pab.)
Rabbit anti-Human CLDN8 Polyclonal Antibody | anti-CLDN8 antibody
CLDN8 Antibody (Center)
Western Blot (WB)
(Western blot analysis of CLDN8 Antibody (Center) in 293 cell line lysates (35ug/lane). CLDN8 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of CLDN8 Antibody (Center) in 293 cell line lysates (35ug/lane). CLDN8 (arrow) was detected using the purified Pab.)
Flow Cytometry (FC/FACS)
(CLDN8 Antibody (Center) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(CLDN8 Antibody (Center) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Osunkoya,A.O., et.al, Hum. Pathol. 40 (2), 206-210 (2009)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010]
Uniprot Description
Claudin-8: Plays a major role in tight junction-specific obliteration of the intercellular space. Belongs to the claudin family.
Protein type: Membrane protein, multi-pass; Endoplasmic reticulum; Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 21q22.11
Cellular Component: tight junction; basolateral plasma membrane; endoplasmic reticulum; plasma membrane; integral to membrane
Molecular Function: identical protein binding; structural molecule activity
Biological Process: calcium-independent cell-cell adhesion
Research Articles on CLDN8
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Product Notes
The CLDN8 cldn8 (Catalog #AAA9212613) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 140-166. The CLDN8 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CLDN8 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS). WB~~1:1000. Researchers should empirically determine the suitability of the CLDN8 cldn8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CLDN8, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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