Western Blot (WB)
(Anti-Cdk6 antibody, MBS176263, Western blottingLane 1: Rat Testis Tissue LysateLane 2: Rat Lung Tissue Lysate )
Rabbit Cdk6 Polyclonal Antibody | anti-CDK6 antibody
Anti-Cdk6 antibody
Western Blot (WB)
(Anti-Cdk6 antibody, MBS176263, Western blottingLane 1: Rat Testis Tissue LysateLane 2: Rat Lung Tissue Lysate )
Western Blot (WB)
(Anti-Cdk6 antibody, MBS176263, Western blottingLane 1: Rat Testis Tissue LysateLane 2: Rat Lung Tissue Lysate )
Background: Cell division protein kinase 6, also called Plstire, is an enzyme that in humans is encoded by the CDK6 gene. The protein encoded by this gene is a member of the cyclin-dependent protein kinase(CDK) family. Radiation hybrid analysis and inclusion within a mapped clone place the CDK6 gene at 7q21. Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation and promotes G1/S transition. This gene also involved in initiation and maintenance of cell cycle exit during cell differentiation. It prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types. CDK6 also plays a role in promoting the proliferation of beta-cells in pancreatic islets of Langerhans.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the cyclin dependent kinase family of proteins that play important roles in the progression and regulation of the cell cycle. The encoded protein binds to a D-type cyclin to form an active kinase complex to regulate progression through the G1 phase of the cell cycle. Mice lacking the encoded protein exhibit thymic and splenic hypoplasia, and hematopoietic defects such as reduced number of megakaryocytes and erythrocytes. A pseudogene of this gene has been defined on chromosome 4. [provided by RefSeq, Aug 2015]
Uniprot Description
CDK6: a protein kinase of the CDK family. Important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. Phosphorylates and regulates the activity of the Rb tumor suppressor protein. Overexpressed and/or disrupted by translocation in leukemias, lymphomas and other cancers and amplified in gliomas and rodent cancers.
Protein type: Kinase, protein; Protein kinase, CMGC; Cell cycle regulation; EC 2.7.11.22; Protein kinase, Ser/Thr (non-receptor); CMGC group; CDK family; CDK4 subfamily; CDK/CDK4 subfamily
Cellular Component: nucleoplasm; ruffle; centrosome; cell projection; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; nucleus
Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; cyclin binding; cyclin-dependent protein kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; ATP binding; protein kinase activity
Biological Process: Notch signaling pathway; negative regulation of myeloid cell differentiation; gliogenesis; T cell differentiation in the thymus; cell cycle; protein amino acid phosphorylation; regulation of cell proliferation; negative regulation of cell cycle; regulation of erythrocyte differentiation; positive regulation of fibroblast proliferation; regulation of gene expression; cell division; cell dedifferentiation; hemopoietic progenitor cell differentiation; hemopoiesis; negative regulation of osteoblast differentiation; positive regulation of cell-matrix adhesion; cell differentiation; phosphorylation; negative regulation of epithelial cell proliferation
Research Articles on CDK6
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Product Notes
The CDK6 cdk6 (Catalog #AAA176263) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Cdk6 antibody reacts with Human, Rat, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Cdk6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the CDK6 cdk6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cdk6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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