Loading...

Skip to main content

Call us on + 1 (800) 604-9114 for more information about our products

Looking for specific datasheet Manual/COA/MSDS?
Request a Manual/COA/MSDS

Interested to get a quote about our products?
Request a Quote

Western Blot (WB) (Mouse Cdk6 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the Cdk6 antibody detected the Cdk6 protein (arrow).)

Rabbit anti-Human Cdk6 Polyclonal Antibody | anti-Cdk6 antibody

Mouse Cdk6 Antibody (C-term)

Gene Names
Cdk6; Crk2; AI504062; 5830411I20
Reactivity
Human
Applications
Western Blot, ELISA
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
Cdk6; Polyclonal Antibody; Mouse Cdk6 Antibody (C-term); Cyclin-dependent kinase 6; CR2 protein kinase; CRK2; Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE; Cdkn6; Crk2; anti-Cdk6 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This Mouse Cdk6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-312 amino acids from the C-terminal region of mouse Cdk6.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
285-312
Sequence Length
326
Applicable Applications for anti-Cdk6 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB~~1:1000
Antigen Type
Synthetic Peptide
Antigen Source
MOUSE
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Mouse Cdk6 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the Cdk6 antibody detected the Cdk6 protein (arrow).)

Western Blot (WB) (Mouse Cdk6 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the Cdk6 antibody detected the Cdk6 protein (arrow).)
Related Product Information for anti-Cdk6 antibody
Cdk6 probably involved in the control of the cell cycle. Interacts with D-type G1 cyclins (By similarity).
Product Categories/Family for anti-Cdk6 antibody
References
Puyol, M., et al. Cancer Cell 18(1):63-73(2010)
Wiedemeyer, W.R., et al. Proc. Natl. Acad. Sci. U.S.A. 107(25):11501-11506(2010)
Rivadeneira, D.B., et al. Gastroenterology 138(5):1920-1930(2010)
Michaud, K., et al. Cancer Res. 70(8):3228-3238(2010)
Choe, K.S., et al. J. Biol. Chem. 285(5):3044-3052(2010)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
37028
NCBI Official Full Name
cyclin-dependent kinase 6
NCBI Official Synonym Full Names
cyclin-dependent kinase 6
NCBI Official Symbol
Cdk6
NCBI Official Synonym Symbols
Crk2; AI504062; 5830411I20
NCBI Protein Information
cyclin-dependent kinase 6
UniProt Protein Name
Cyclin-dependent kinase 6
Protein Family
UniProt Gene Name
Cdk6
UniProt Synonym Gene Names
Cdkn6; Crk2; CRK2
UniProt Entry Name
CDK6_MOUSE

NCBI Description

This gene encodes a member of the cyclin dependent kinase family of proteins that play important roles in the progression and regulation of the cell cycle. The encoded protein binds to a D-type cyclin to form an active kinase complex to regulate progression through the G1 phase of the cell cycle. Mice lacking the encoded protein exhibit thymic and splenic hypoplasia, and hematopoietic defects such as reduced number of megakaryocytes and erythrocytes. A pseudogene of this gene has been defined on chromosome 4. [provided by RefSeq, Aug 2015]

Uniprot Description

CDK6: a protein kinase of the CDK family. Important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. Phosphorylates and regulates the activity of the Rb tumor suppressor protein. Overexpressed and/or disrupted by translocation in leukemias, lymphomas and other cancers and amplified in gliomas and rodent cancers.

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; Cell cycle regulation; EC 2.7.11.22; Kinase, protein; CMGC group; CDK family; CDK/CDK4 subfamily; CDK4 subfamily

Cellular Component: nucleoplasm; ruffle; centrosome; cell projection; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; nucleus

Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; cyclin binding; cyclin-dependent protein kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; ATP binding; protein kinase activity

Biological Process: Notch signaling pathway; negative regulation of myeloid cell differentiation; gliogenesis; T cell differentiation in the thymus; cell cycle; protein amino acid phosphorylation; negative regulation of cell cycle; regulation of cell proliferation; regulation of erythrocyte differentiation; positive regulation of fibroblast proliferation; cell division; regulation of gene expression; cell dedifferentiation; hemopoiesis; negative regulation of osteoblast differentiation; hemopoietic progenitor cell differentiation; positive regulation of cell-matrix adhesion; cell differentiation; phosphorylation; negative regulation of epithelial cell proliferation

Research Articles on Cdk6

Similar Products

Product Notes

The Cdk6 cdk6 (Catalog #AAA9208142) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 285-312. The Mouse Cdk6 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Cdk6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the Cdk6 cdk6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cdk6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

Item has been added to Shopping Cart

If you are ready to order, navigate to Shopping Cart and get ready to checkout.

Looking for a specific manual?
Request a Manual

Request more Information

Please complete the form below and a representative will contact you as soon as possible.

Request a Manual

Please complete the form below and a representative will contact you as soon as possible.

Request a Quote

Please complete the form below and a representative will contact you as soon as possible.