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Rabbit anti-Human CD48 (BCM1) Polyclonal Antibody | anti-CD48 antibody

Rabbit anti Human CD48 (BCM1) Polyclonal

Reactivity
Human
Applications
ELISA
Purity
Serum IgG fraction was purified by Protein A affinity chromatography.
Synonyms
CD48 (BCM1); Polyclonal Antibody; Rabbit anti Human CD48 (BCM1) Polyclonal; Rabbit anti Human CD48 (BCM1) Polyclonal purified; cd48; cd-48; BCM1polyclonal; PAb; anti-CD48 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Serum IgG fraction was purified by Protein A affinity chromatography.
Form/Format
0.2 um filtered solution in PBS with 5% trehalose.
Sequence Length
243
Applicable Applications for anti-CD48 antibody
ELISA (EIA)
Application Notes
ELISA: Use at a concentration range of 0.5-1ug/ml. The detection limit for CD48 is approximately 0.16 ng/well.
Source Note
Polyclonal CD48 antibody was produced from sera of rabbits immunized with recombinant human CD48.
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers.
Preparation and Storage
The lyophilized antibody is stable for at least 1 year from date of receipt at -20 degree C.
Upon reconstitution, this antibody can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
Shelf Life: >12 months
Related Product Information for anti-CD48 antibody
CD48 is a glycosylphosphatidylinositol -anchored protein belonging to the CD2 subfamily. It is expressed mainly on hematopoietic cells and exists in both membrane- associated and soluble forms. It is a low-affinity ligand for CD2 and is implicated as an important costimulatory molecule in lymphocyte activation. Indeed, CD48 has been described as facilitating cell adhesion, innate responses to bacterial infection, and graft rejection. In addition, CD48 is a high- affinity ligand for 2B4. CD48-2B4 interactions can modulate T cell, B cell, and natural killer (NK) cell functions and cross-talk.The absence of functional 2B4- CD48 interactions impairs NK cell cytotoxic response and IFN- release on tumor target exposure. Furthermore, activated NK cells significantly increase the CD3-dependent proliferation of CD8+ and CD4+ T cells by a 2B4-CD48-dependent mechanism.
Product Categories/Family for anti-CD48 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
962
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
27,683 Da
NCBI Official Full Name
CD48 antigen isoform 1
UniProt Protein Name
CD48 antigen
Protein Family
UniProt Gene Name
CD48
UniProt Synonym Gene Names
BCM1; BLAST1; SLAMF2
UniProt Entry Name
CD48_HUMAN

NCBI Description

This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Description

CD48: Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 1q21.3-q22

Cellular Component: membrane; integral to plasma membrane; plasma membrane; lipid raft

Molecular Function: protein binding; receptor activity

Biological Process: defense response; blood coagulation; leukocyte migration

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Product Notes

The CD48 cd48 (Catalog #AAA551031) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti Human CD48 (BCM1) Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD48 (BCM1) can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). ELISA: Use at a concentration range of 0.5-1ug/ml. The detection limit for CD48 is approximately 0.16 ng/well. Researchers should empirically determine the suitability of the CD48 cd48 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD48 (BCM1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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