Western Blot (WB)
(UBE2V2 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the UBE2V2 antibody detected the UBE2V2 protein (arrow).)
Rabbit UBE2V2 Polyclonal Antibody | anti-UBE2V2 antibody
UBE2V2 Antibody (Center)
Western Blot (WB)
(UBE2V2 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the UBE2V2 antibody detected the UBE2V2 protein (arrow).)
Western Blot (WB)
(UBE2V2 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the UBE2V2 antibody detected the UBE2V2 protein (arrow).)
constitute a distinct subfamily within the E2 protein family. They
have sequence similarity to other ubiquitin-conjugating enzymes but
lack the conserved cysteine residue that is critical for the
catalytic activity of E2s. The protein encoded by this gene also
shares homology with ubiquitin-conjugating enzyme E2 variant 1 and
yeast MMS2 gene product. It may be involved in the differentiation
of monocytes and enterocytes.
Brun, J., et al. BMC Mol. Biol. 9, 24 (2008) :
Pastushok, L., et al. FEBS Lett. 581(28):5343-5348(2007)
Zhao, G.Y., et al. Mol. Cell 25(5):663-675(2007)
Wen, R., et al. Plant Mol. Biol. 61 (1-2), 241-253 (2006) :
NCBI and Uniprot Product Information
NCBI Description
Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, Jul 2008]
Uniprot Description
UBE2V2: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Belongs to the ubiquitin-conjugating enzyme family.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 8q11.21
Cellular Component: cytoplasm; nucleus; UBC13-MMS2 complex
Molecular Function: protein binding; small conjugating protein ligase activity; ubiquitin protein ligase binding
Biological Process: regulation of DNA repair; positive regulation of synaptogenesis; cell proliferation; protein polyubiquitination; positive regulation of DNA repair; postreplication repair; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; DNA double-strand break processing; protein ubiquitination; negative regulation of neuron apoptosis
Research Articles on UBE2V2
Similar Products
Product Notes
The UBE2V2 ube2v2 (Catalog #AAA9210692) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 75-104. The UBE2V2 Antibody (Center) reacts with Human (Predicted Reactivity: Bovine, Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's UBE2V2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the UBE2V2 ube2v2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "UBE2V2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
