Immunohistochemistry (IHC)
Rabbit CD31/Pecam1 Polyclonal Antibody | anti-Pecam1 antibody
Anti-CD31/Pecam1 Antibody
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
IHC-P (Embedded Section): 0.5-1ug/ml (Human, Rat)
Direct ELISA: 0.1-0.5ug/ml (Rat)
Tested Species: In-house tested species with positive results.
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Western Blot (WB)
(Figure 1. Western blot analysis of Pecam1 using anti-Pecam1 antibody.)
Western Blot (WB)
(Figure 1. Western blot analysis of Pecam1 using anti-Pecam1 antibody.)
Background: CD31 also known as Platelet endothelial cell adhesion molecule (PECAM-1), is a protein that in human is encoded by the PECAM1 gene. Encoded protein is a member of the immunoglobulin superfamily and this gene is mapped to 17q23.3. CD31 is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. It is demonstrated that CD31 expression on human PBSCs may positively affect both neutrophil and platelet engraftment. Meanwhile, CD31 is involved in leukocyte migration and angiogenesis, which are key components of venous thrombus resolution.
2. Wu, Y., Tworkoski, K., Michaud, M., Madri, J. A. Bone marrow monocyte PECAM-1 deficiency elicits increased osteoclastogenesis resulting in trabecular bone loss. J. Immun. 182: 2672-2679, 2009.
3. Xie, Y., Muller, W. A. Fluorescence in situ hybridization mapping of the mouse platelet endothelial cell adhesion molecule-1 (PECAM1) to mouse chromosome 6, region F3-G1. Genomics 37: 226-228, 1996.
NCBI and Uniprot Product Information
NCBI Description
cell adhesion molecule, also intracellular signaling molecule; may mediate leukocyte adhesion and migration, angiogenesis, and thrombosis [RGD, Feb 2006]
Uniprot Description
PECAM-1: a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Plays a role in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, cell migration, negative regulation of immune cell signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. Undergoes alternative splicing, generating multiple isoforms in vascular beds of various tissues.
Protein type: Cell adhesion; Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis
Cellular Component: cell surface; external side of plasma membrane; extracellular space; lipid raft; membrane; plasma membrane; ruffle; smooth muscle contractile fiber
Molecular Function: protein phosphatase binding
Biological Process: angiogenesis; diapedesis; endothelial cell migration; endothelial cell morphogenesis; negative regulation of actin filament polymerization; negative regulation of peptidyl-tyrosine phosphorylation; phagocytosis; positive regulation of cellular extravasation; positive regulation of leukocyte migration; positive regulation of tyrosine phosphorylation of Stat5 protein; regulation of cell migration; Rho protein signal transduction; wound healing
Research Articles on Pecam1
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Product Notes
The Pecam1 pecam1 (Catalog #AAA1752990) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CD31/Pecam1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CD31/Pecam1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Direct ELISA (EIA). WB: 0.1-0.25ug/ml (Mouse, Rat) IHC-P (Embedded Section): 0.5-1ug/ml (Human, Rat) Direct ELISA: 0.1-0.5ug/ml (Rat) Tested Species: In-house tested species with positive results. Researchers should empirically determine the suitability of the Pecam1 pecam1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD31/Pecam1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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