Immunohistochemistry (IHC)
Rabbit anti-Human, Mouse Scramblase 1/Plscr1 Polyclonal Antibody | anti-Plscr1 antibody
Anti-Scramblase 1/Plscr1 Antibody
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
IHC-P (Embedded Section): 0.5-1ug/ml (Mouse)
Direct ELISA: 0.1-0.5ug/ml (Mouse)
Tested Species: In-house tested species with positive results.
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Western Blot (WB)
(Figure 1. Western blot analysis of Plscr1 using anti-Plscr1 antibody.)
Western Blot (WB)
(Figure 1. Western blot analysis of Plscr1 using anti-Plscr1 antibody.)
Background: Phospholipid scramblase 1 is a protein that in human is encoded by the PLSCR1 gene. This gene is mapped to 9; 9 E3.3.
2. Kametaka, S., Shibata, M., Moroe, K., Kanamori, S., Ohsawa, Y., Waguri, S., Sims, P. J., Emoto, K., Umeda, M., Uchiyama, Y. Identification of phospholipid scramblase 1 as a novel interacting molecule with beta-secretase (beta-site amyloid precursor protein (APP) cleaving enzyme (BACE). J. Biol. Chem. 278: 15239-15245, 2003.
3. Kasukabe, T., Kobayashi, H., Kaneko, Y., Okabe-Kado, J., Honma, Y. Identity of human normal counterpart (MmTRA1b) of mouse leukemogenesis-associated gene (MmTRA1a) product as a plasma membrane phospholipid scramblase and chromosome mapping of the human MmTRA1b/phospholipid scramblase gene. Biochem. Biophys. Res. Commun. 249: 449-455, 1998.
NCBI and Uniprot Product Information
Uniprot Description
PLSCR1: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Belongs to the phospholipid scramblase family.
Protein type: Calcium-binding; Membrane protein, integral
Cellular Component: cytosol; extracellular matrix; Golgi apparatus; integral to membrane; integral to plasma membrane; lipid raft; membrane; nucleolus; nucleus; plasma membrane
Molecular Function: calcium ion binding; CD4 receptor binding; DNA binding; enzyme binding; epidermal growth factor receptor binding; phospholipid scramblase activity; SH3 domain binding
Biological Process: apoptosis; defense response to virus; immune response; myeloid cell differentiation; negative regulation of protein binding; negative regulation of viral genome replication; phosphatidylserine biosynthetic process; phospholipid scrambling; positive regulation of apoptosis; positive regulation of innate immune response; positive regulation of transcription from RNA polymerase II promoter; regulation of mast cell activation; transcription from RNA polymerase II promoter
Research Articles on Plscr1
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Product Notes
The Plscr1 plscr1 (Catalog #AAA1753063) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Scramblase 1/Plscr1 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Scramblase 1/Plscr1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Direct ELISA (EIA). WB: 0.1-0.25ug/ml (Human, Mouse) IHC-P (Embedded Section): 0.5-1ug/ml (Mouse) Direct ELISA: 0.1-0.5ug/ml (Mouse) Tested Species: In-house tested species with positive results. Researchers should empirically determine the suitability of the Plscr1 plscr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Scramblase 1/Plscr1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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