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Testing Data

Rabbit Cathepsin L Polyclonal Antibody | anti-Ctsl antibody

Cathepsin L (Cleaved) Antibody

Gene Names
Ctsl; CatL; CATHL; Ctsl1
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry
Purity
Affinity purified
Synonyms
Cathepsin L; Polyclonal Antibody; Cathepsin L (Cleaved) Antibody; CTSL1; CATL; CTSL; MEP; FLJ31037; EC 3.4.22.15; OTTHUMP00000063566; anti-Ctsl antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity purified
Form/Format
100 ug (0.5 mg/ml purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 1% BSA, and 0.02% thimerosal.
Appearance: Colorless liquid
Concentration
0.5 mg/ml (varies by lot)
Sequence Length
334
Applicable Applications for anti-Ctsl antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
Western blotting (0.5-4 ug/ml). However, the optimal concentrations should be determined individually. The antibody recognizes the mature form of Cathepsin L (25 kDa) from human, mouse and rat origins. Reactivity to other species has not been tested. Rat kidney tissue lysate can be used as a positive control.
Immunogen
Synthetic peptide surrounding amino acid 223 of rat Cathepsin L
Handling
The antibody solution should be gently mixed before use.
Preparation and Storage
At -20 degree C
Shelf Life: 12 months

Testing Data

Testing Data
Related Product Information for anti-Ctsl antibody
Background: The cysteine proteases termed lysosomal cathepsins have long been thomught to be primarily involved in end-stage protein breakdown within lysosomal compartments. Cathepsin L functions to regulate cell cycle progression thromugh proteolytic processing of the CDP/Cux transcription factor.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
37,660 Da
NCBI Official Full Name
cathepsin L1 preproprotein
NCBI Official Synonym Full Names
cathepsin L
NCBI Official Symbol
Ctsl
NCBI Official Synonym Symbols
CatL; CATHL; Ctsl1
NCBI Protein Information
cathepsin L1
UniProt Protein Name
Cathepsin L1
Protein Family
UniProt Gene Name
Ctsl
UniProt Synonym Gene Names
Ctsl1; CP-2; MEP
UniProt Entry Name
CATL1_RAT

NCBI Description

mouse homolog is deleted in the CD4 T-cell-deficient mouse mutant nacht (nkt); may play a role in CD4+ T-cell selection in the thymus [RGD, Feb 2006]

Uniprot Description

CTSL2: Cysteine protease. May have an important role in corneal physiology. Belongs to the peptidase C1 family.

Protein type: EC 3.4.22.15; Secreted; Secreted, signal peptide; Protease

Cellular Component: extracellular space; neuron projection; microvillus; apical part of cell; lysosome; cytoplasm; nucleolus; perikaryon; vacuole; cytoplasmic vesicle; nucleus; secretory granule; external side of plasma membrane

Molecular Function: collagen binding; proteoglycan binding; histone binding; fibronectin binding; cysteine-type endopeptidase activity; protein complex binding; cysteine-type carboxypeptidase activity; aminopeptidase activity; kininogen binding; peptide binding; cysteine-type peptidase activity

Biological Process: adaptive immune response; hair follicle morphogenesis; response to glucocorticoid stimulus; male gonad development; Sertoli cell differentiation; multicellular organismal aging; decidualization; cellular response to starvation; proteolysis; response to organic cyclic substance; collagen catabolic process; protein autoprocessing; proteolysis involved in cellular protein catabolic process; autophagic cell death; response to glucose stimulus; cell communication; spermatogenesis; nerve development; protein processing

Research Articles on Ctsl

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Product Notes

The Ctsl ctsl (Catalog #AAA841163) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cathepsin L (Cleaved) Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Cathepsin L can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western blotting (0.5-4 ug/ml). However, the optimal concentrations should be determined individually. The antibody recognizes the mature form of Cathepsin L (25 kDa) from human, mouse and rat origins. Reactivity to other species has not been tested. Rat kidney tissue lysate can be used as a positive control. Researchers should empirically determine the suitability of the Ctsl ctsl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cathepsin L, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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