Western Blot (WB)
(Western Blot: Sample: Rat Heart lysate; Primary Ab: 2ug/ml Rabbit Anti-Mouse CDHH Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Rabbit anti-Mouse Cadherin, Heart (CDHH) Polyclonal Antibody | anti-CDHH antibody
Polyclonal Antibody to Cadherin, Heart (CDHH)
MRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF-YPD PMMVTKQENI SVGSVLLTVN ATDPDSLQHQ TIRYSIYKDP AGWLSINPIN GTVDTTAVLD RESPFVHNSV YTALFLAIDS GNPPATGTGT LLITLEDIND NAPVIYPTVA EVCDDARNLS VVILGASDKD LHPNTDPFKF EIHKQTVPDK VWKISKINNT HALVSLLQNL NKANYNLPIMVTDSGKPPMT NITDLRVQVC SCKNSKVDCN
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Rat Heart lysate; Primary Ab: 2ug/ml Rabbit Anti-Mouse CDHH Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Western Blot (WB)
(Western Blot: Sample: Rat Heart lysate; Primary Ab: 2ug/ml Rabbit Anti-Mouse CDHH Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Heart Tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Heart Tissue))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. This gene is highly expressed in the vasculature including endothelial cells, smooth muscle cells and pericytes, where the encoded protein binds to adiponectin and has been implicated in the modulation of angiogenesis. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Nov 2015]
Uniprot Description
CDH13: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 8 E1|8 65.97 cM
Cellular Component: caveola; cytoplasm; external side of plasma membrane; extracellular matrix; extracellular space; focal adhesion; membrane; neuron projection; perinuclear region of cytoplasm; plasma membrane
Molecular Function: adiponectin binding; cadherin binding; calcium ion binding; low-density lipoprotein particle binding; metal ion binding; protein binding; protein homodimerization activity
Biological Process: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell adhesion; endothelial cell migration; homophilic cell adhesion; keratinocyte proliferation; lamellipodium assembly; localization within membrane; low density lipoprotein mediated signaling; negative regulation of cell adhesion; negative regulation of cell proliferation; positive regulation of calcium-mediated signaling; positive regulation of cell migration; positive regulation of cell-matrix adhesion; positive regulation of endothelial cell proliferation; positive regulation of positive chemotaxis; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; Rac protein signal transduction; regulation of endocytosis; regulation of epidermal growth factor receptor signaling pathway; Rho protein signal transduction; sprouting angiogenesis
Research Articles on CDHH
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Product Notes
The CDHH cdh13 (Catalog #AAA2006317) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Cadherin, Heart (CDHH) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Cadherin, Heart (CDHH) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the CDHH cdh13 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below. MRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF -YPD PMMVTKQENI SVGSVLLTVN ATDPDSLQHQ TIRYSIYKDP AGWLSINPIN GTVDTTAVLD RESPFVHNSV YTALFLAIDS GNPPATGTGT LLITLEDIND NAPVIYPTVA EVCDDARNLS VVILGASDKD LHPNTDPFKF EIHKQTVPDK VWKISKINNT HALVSLLQNL NKANYNLPIM VTDSGKPPMT NITDLRVQVC SCKNSKVDCN. It is sometimes possible for the material contained within the vial of "Cadherin, Heart (CDHH), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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