Immunohistochemistry (IHC)
(Immunochemical staining of human BTRC in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human BTRC Polyclonal Antibody | anti-BTRC antibody
Anti-BTRC Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
BTRC; Polyclonal Antibody; Anti-BTRC Antibody; Rabbit Polyclonal; BTRC Antibody; Rabbit PAb; Antigen Affinity Purified; beta-transducin repeat containing E3 ubiquitin protein ligase; Anti-BETA-TRCP Antibody; Anti-betaTrCP Antibody; Anti-bTrCP Antibody; Anti-bTrCP1 Antibody; Anti-FBW1A Antibody; Anti-FBXW1 Antibody; Anti-FBXW1A Antibody; Anti-FWD1 Antibody; anti-BTRC antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human BTRC
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-BTRC antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:50-1:200
Immunogen
E Coli-derived Human BTRC fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human BTRC fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human BTRC in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human BTRC in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human BTRC in human rectum with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human BTRC in human rectum with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-BTRC antibody
The BTRC gene (beta-transducin repeat-containing protein) is a human homolog of Slimb that is located at 10q24.3, a chromosome region frequently deleted in medulloblastomas. PAQR3 forms a complex with Twist1 and BTRC, an E3 ubiquitin ligase. PAQR3 enhances the interaction between Twist1 and BTRC. Twist1 is mobilized from the nucleus to a proteasome-containing structure in the cytoplasm upon overexpression of PAQR3 and BTRC, which is required for PAQR3-induced degradation of Twist1. The Twist1 box domain of the Twist1 protein is required for the interaction of Twist1 with both PAQR3 and BTRC, indispensable for PAQR3-mediated degradation of Twist1. Circular RNA FAM169A (circ-FAM169A) promotes IDD development via miR-583/BTRC signaling. The finding provides a potential therapeutic option for the treatment of intervertebral disc degeneration (IDD).
References
Wolter M, et al. (2003) Absence of detectable alterations in the putative tumor suppressor gene btrc in cerebellar medulloblastomas and cutaneous basal cell carcinomas. Acta Neuropathol 106 (4): 287-290.
Guo W, et al. (2020) The circular rna fam169a functions as a competitive endogenous rna and regulates intervertebral disc degeneration by targeting mir-583 and btrc. Cell Death Dis 11 (5): 315.Guo W, et al. (2016) Paqr3 enhances twist1 degradation to suppress epithelial-mesenchymal transition and metastasis of gastric cancer cells. Carcinogenesis 37 (4): 397-407.
Guo W, et al. (2020) The circular rna fam169a functions as a competitive endogenous rna and regulates intervertebral disc degeneration by targeting mir-583 and btrc. Cell Death Dis 11 (5): 315.Guo W, et al. (2016) Paqr3 enhances twist1 degradation to suppress epithelial-mesenchymal transition and metastasis of gastric cancer cells. Carcinogenesis 37 (4): 397-407.
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Product Notes
The BTRC (Catalog #AAA8110375) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-BTRC Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's BTRC can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:50-1:200. Researchers should empirically determine the suitability of the BTRC for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BTRC, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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