Western Blot (WB)
(BEAN Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the BEAN antibody detected the BEAN protein (arrow).)
Rabbit anti-Human BEAN Polyclonal Antibody | anti-BEAN1 antibody
BEAN Antibody (N-term)
Western Blot (WB)
(BEAN Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the BEAN antibody detected the BEAN protein (arrow).)
Western Blot (WB)
(BEAN Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the BEAN antibody detected the BEAN protein (arrow).)
Immunohistochemistry (IHC)
(BEAN Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of BEAN Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(BEAN Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of BEAN Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
proteins that interact with NEDD4, a member of a family of
ubiquitin-protein ligases. These proteins have PY motifs in common
that bind to the WW domains of NEDD4. NEDD4 is developmentally
regulated, and is highly expressed in embryonic tissues. Mutations
in this gene (i.e., intronic insertions of >100 copies of
pentanucleotide repeats including a (TGGAA)n sequence) are
associated with spinocerebellar ataxia type 31. Alternatively
spliced transcript variants encoding different isoforms have been
found for this gene.
Jolliffe, C.N., et al. Biochem. J. 351 PT 3, 557-565 (2000) :
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is one of several proteins that interact with NEDD4, a member of a family of ubiquitin-protein ligases. These proteins have PY motifs in common that bind to the WW domains of NEDD4. NEDD4 is developmentally regulated, and is highly expressed in embryonic tissues. Mutations in this gene (i.e., intronic insertions of >100 copies of pentanucleotide repeats including a (TGGAA)n sequence) are associated with spinocerebellar ataxia type 31. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Uniprot Description
BEAN: Defects in BEAN1 are the cause of spinocerebellar ataxia type 31 (SCA31); also known as spinocerebellar ataxia 16q22-linked. A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA31 belongs to the autosomal dominant cerebellar ataxias type III (ADCA III) which are characterized by pure cerebellar ataxia without additional signs. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 16q21
Cellular Component: integral to membrane
Disease: Spinocerebellar Ataxia 31
Research Articles on BEAN1
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Product Notes
The BEAN1 bean1 (Catalog #AAA9212061) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 45-73. The BEAN Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's BEAN can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the BEAN1 bean1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BEAN, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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