Rabbit anti-Human BCMA Polyclonal Antibody | anti-TNFRSF17 antibody

BCMA Antibody

Cat. Num. AAA151091

• Gene Names: TNFRSF17; BCM; BCMA; CD269; TNFRSF13A
• Reactivity: Human
• Applications: ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
• Purity: BCMA Antibody is affinity chromatography purified via peptide column.
• Synonyms: BCMA; Polyclonal Antibody; BCMA Antibody; BCM; CD269; TNFRSF13A; Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; tumor necrosis factor receptor superfamily; member 17; anti-TNFRSF17 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: BCMA Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid; Supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 184

• Applicable Applications for anti-TNFRSF17 antibody: ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry-Paraffin (IHC-P), Western Blot (WB)
• Application Notes: BCMA antibody can be used for detection of BCMA by Western blot at 5 ug/mL. Antibody can also be used for immunohistochemistry starting at 5 ug/mL. For immunofluorescence start at 20 ug/mL.; ; Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.; ; Optimal dilutions for each application to be determined by the researcher.
• Conjugate: Unconjugated
• Immunogen: BCMA antibody was raised against a synthetic peptide mapping at the carboxy terminus of human BCMA.; The immunogen is located within the last 50 amino acids of BCMA.
• Positive Control: 1) Cat. No. MBS151739 - K562 Cell Lysate; 2) Cat. No. MBS151695 - U937 Cell Lysate; 3) Cat. No. MBS151674 - Human Spleen Tissue Lysate; 4) Cat. No. MBS154333 - Human Spleen Tissue Slide
• Preparation and Storage: BCMA antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of BCMA in (A) human spleen tissue lysate, (B) K562, and (C) U937 cell lysates with BCMA antibody at 5 μg/mL. )

Immunohistochemistry (IHC)

(Immunohistochemistry of BCMA in human spleen tissue with BCMA antibody at 5 μg/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of BCMA in human spleen tissue with BCMA antibody at 10 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of BCMA in Human Spleen tissue with BCMA antibody at 10 μg/mL.)

Related Product Information for anti-TNFRSF17 antibody

BCMA Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFF-R, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-κB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.

NCBI and Uniprot Product Information

• NCBI GI #: 23238192
• NCBI GeneID: 608
• NCBI Accession #: NP_001183
• NCBI GenBank Nucleotide #: NM_001192.2
• UniProt Accession #: Q02223; Q2TQ40
• Molecular Weight: Predicted: 20 kDa; Observed: 27 kDa
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 17
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily, member 17
• NCBI Official Symbol: TNFRSF17
• NCBI Official Synonym Symbols: BCM; BCMA; CD269; TNFRSF13A
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 17; B-cell maturation factor; B cell maturation antigen; B-cell maturation protein
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 17
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: TNFRSF17
• UniProt Synonym Gene Names: BCM; BCMA
• UniProt Entry Name: TNR17_HUMAN

NCBI Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]

Uniprot Description

TNFRSF17: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.

Protein type: Oncoprotein; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 16p13.1

Cellular Component: integral to membrane; plasma membrane; endomembrane system

Molecular Function: receptor activity

Biological Process: cell proliferation; immune system process; multicellular organismal development; signal transduction