B-cell Maturation (TNFRSF17) Recombinant Protein | TNFRSF17 recombinant protein

B-cell Maturation Protein (TNFRSF17)

Cat. Num. AAA516632

• Gene Names: TNFRSF17; BCM; BCMA; CD269; TNFRSF13A
• Applications: Cell Assay
• Synonyms: B-cell Maturation (TNFRSF17); B-cell Maturation Protein (TNFRSF17); Tumor necrosis factor receptor superfamily member 17; TNFRSF17; B cell maturation antigen; BCM; BCMA; CD269.; TNFRSF17 recombinant protein

• Host: E Coli
• Form/Format: Lyophilized from a 0.2 um filtered solution in PBS

• Applicable Applications for TNFRSF17 recombinant protein: Cell Assay
• Species: Human
• Endotoxin Level: <1.0EU/ug of recombinant protein as determined by the LAL method.
• Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1mg/ml. This solution can then be diluted into other buffers.
• Preparation and Storage: The lyophilized protein is stable for at least one year from date of receipt at -70 degree C. Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree -8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

SDS-Page

(Purity: Recombinant Human B-cell Maturation Protein (TNFRSF17) resolved on a 17% SDS-PAGE gel under reducing conditions and stained with Coomassie Brilliant Blue G-250.)

Related Product Information for TNFRSF17 recombinant protein

Recombinant Human B-cell Maturation Protein (TNFRSF17) was expressed in E Coli cells. The protein accession number is Q02223
BCMA (B cell maturation) is a nonglycosylated integral membrane type I protein that is preferentially expressed in mature B lymphocytes.The N-terminal part of both mouse and human proteins contains a conserved six-cysteine motif. BLyS binds to three receptors of the TNF receptor family (B cell maturation antigen BCMA, TACI, and BAFF-R), all of which are expressed by mature B cells.

Product Categories/Family for TNFRSF17 recombinant protein

Growth Factors; Cancer

NCBI and Uniprot Product Information

• NCBI GI #: 23238192
• NCBI GeneID: 608
• NCBI Accession #: NP_001183.2
• NCBI GenBank Nucleotide #: NM_001192.2
• UniProt Accession #: Q02223; Q2TQ40
• Molecular Weight: 14,843 Da
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 17
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily, member 17
• NCBI Official Symbol: TNFRSF17
• NCBI Official Synonym Symbols: BCM; BCMA; CD269; TNFRSF13A
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 17; B cell maturation antigen; B-cell maturation factor; B-cell maturation protein
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 17
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: TNFRSF17
• UniProt Synonym Gene Names: BCM; BCMA
• UniProt Entry Name: TNR17_HUMAN

NCBI Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]

Uniprot Description

TNFRSF17: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.

Protein type: Membrane protein, integral; Oncoprotein; Receptor, misc.

Chromosomal Location of Human Ortholog: 16p13.1

Cellular Component: integral to membrane; plasma membrane; endomembrane system

Molecular Function: receptor activity

Biological Process: cell proliferation; immune system process; multicellular organismal development; signal transduction