BCMA/TNFRSF17 Biotinylated Recombinant Protein | BCMA/TNFRSF17 recombinant protein

Recombinant Human BCMA/TNFRSF17 (C-Fc-Avi) Biotinylated

Cat. Num. AAA2569040

• Gene Names: TNFRSF17; BCM; BCMA; CD269; TNFRSF13A
• Purity: >90% as determined by reducing SDS-PAGE
• Synonyms: BCMA/TNFRSF17 Biotinylated; Recombinant Human BCMA/TNFRSF17 (C-Fc-Avi) Biotinylated; Tumor necrosis factor receptor superfamily member 17; TNFRSF17; B-cell maturation protein; CD269; BCMA/TNFRSF17 recombinant protein

• Host: Human Cells
• Purity/Purification: >90% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of PBS, pH7.4.
• Sequence: Met1-Ala54

• Species: Human
• Tag: C-Fc-Avi
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Biotinylated Recombinant Human B-cell Maturation Protein is produced by our Mammalian expression system and the target gene encoding Met1-Ala54 is expressed with a Fc, Avi tag at the C-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for BCMA/TNFRSF17 recombinant protein

B cell maturation protein (BCMA) is a type III membrane protein which belongs to the TNF receptor superfamily (TNFRSF17). BCMA contains one extracellular cysteine rich domain, as well as TACI. Human BCMA is a 184 amino acid (aa) protein consisting of a 54 aa extracellular domain, a 23 aa transmembrane domain, and a 107 aa intracellular domain. Mouse and human BCMA share 62% amino acid identity. BCMA is mainly expressed in immune organs and mature B cell lines. BCMA appears to be localized to the Golgi compartment. BCMA may play an important role in B cell development, function and regulation.

Product Categories/Family for BCMA/TNFRSF17 recombinant protein

Signal Transduction; Cancer; immunology

NCBI and Uniprot Product Information

• NCBI GI #: 23238192
• NCBI GeneID: 608
• NCBI Accession #: NP_001183.2
• NCBI GenBank Nucleotide #: NM_001192.2
• UniProt Accession #: Q02223; Q2TQ40
• Molecular Weight: 14,843 Da
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 17
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily, member 17
• NCBI Official Symbol: TNFRSF17
• NCBI Official Synonym Symbols: BCM; BCMA; CD269; TNFRSF13A
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 17; B cell maturation antigen; B-cell maturation factor; B-cell maturation protein
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 17
• UniProt Gene Name: TNFRSF17
• UniProt Synonym Gene Names: BCM; BCMA
• UniProt Entry Name: TNR17_HUMAN

NCBI Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]

Uniprot Description

TNFRSF17: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.

Protein type: Membrane protein, integral; Oncoprotein; Receptor, misc.

Chromosomal Location of Human Ortholog: 16p13.1

Cellular Component: integral to membrane; plasma membrane; endomembrane system

Molecular Function: receptor activity

Biological Process: cell proliferation; immune system process; multicellular organismal development; signal transduction