Rabbit Bcl-2 related protein A1 Polyclonal Antibody | anti-Bcl2a1a antibody
Polyclonal Antibody to Bcl-2 related protein A1
Reactivity
Gerbil, Mouse, RatPredicted: Human
Applications
Western Blot, Immunohistochemistry, Immunoprecipitation
Purity
Serum
Synonyms
Bcl-2 related protein A1; Polyclonal Antibody; Polyclonal Antibody to Bcl-2 related protein A1; Bcl2a1a; Bcl2a1d; Antibody to Bcl-2 related protein A1; Anti-Bcl-2 related protein A1 Antibody; Bcl-2 related protein A1 Antibody; anti-Bcl2a1a antibody
Host
Rabbit
Reactivity
Gerbil, Mouse, Rat
Predicted: Human
Predicted: Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Serum
Form/Format
50 ul sera
Sequence Length
172
Applicable Applications for anti-Bcl2a1a antibody
Western Blot (WB), Immunohistochemistry (IHC) Formalin/Paraffin, Immunoprecipitation (IP)
Application Notes
WB: 1: 1000-1: 2000
IHC (paraffin): 1: 1000-1: 5000
IP: 1: 50-1: 200
IHC (paraffin): 1: 1000-1: 5000
IP: 1: 50-1: 200
Immunogen Information
A synthetic peptide of Bcl-2 related protein A1 (amino acids 34-51 CRVLQRVAFSVQKEVEKN) of mouse A1 was used as immunogen for this antibody
Antigen
Bcl-2 related protein A1
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
Related Product Information for anti-Bcl2a1a antibody
The Bcl-2 families of apoptosis-related genes plays central roles in regulating apoptotic pathways (Regulation of cell death through apoptosis is critical for the maintenance of homeostasis, defense against infectious agents, and normal development. Bcl-2 family proteins regulate apoptosis primarily through the regulation of mitochondrial outer membrane permeability. Bcl-2 family proteins can be divided into 3 main subfamilies on the basis of their function and the content of their Bcl-2 homology (BH) domains, for example: 1) Prosurvival: Bcl-2, Bcl-XL, Bcl-W, A1, and Mcl-1 2) Proapoptotic (multidomain): Bax, Bak, and Bok. 3) BH3-only (proapoptotic): Bad, Bcl-XS, Bid, Bik, Bim, Blk, Bmf, Bnip, Noxa, and Puma. This antibody recognizes A1 isoforms containing the peptide immungen sequence including A1-a, A1-b, and A1-d. Mouse A1-a is a 172 amino acid (aa) protein. Mouse A1-b has been described as both a 140 aa protein and Mouse A1-d is a 172 aa protein. Prosurvival members inhibit cells from undergoing apoptosis, whereas proapoptotic and BH3-only subfamily members promote apoptosis. There are 4 BH domains (1-4) conserved among Bcl-2 family proteins. Overall, the relative ratio of prosurvival and proapoptotic proteins determines the suseptibility of a cell to various apoptotic stimuli.Many Bcl-2 family proteins are differentially expressed in various malignancies and some are useful prognostic biomarkers. Prosurvival proteins are often elevated in diverse cancers and have the potential to confer resistance to both endogenous cell death stimuli and cancer treatments. Alterations in the ratio or levels of Bcl-2 family proteins have been also associated with nonmalignant diseases including neurodegenerative diseases, autoimmune diseases, AIDs, Downs syndrome, cardiovascular diseases, diabetes, glomerulonephritis, and muscular dystrophy.
Product Categories/Family for anti-Bcl2a1a antibody
NCBI and Uniprot Product Information
Similar Products
Product Notes
The Bcl2a1a bcl2a1a (Catalog #AAA668539) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Bcl-2 related protein A1 reacts with Gerbil, Mouse, Rat Predicted: Human and may cross-react with other species as described in the data sheet. AAA Biotech's Bcl-2 related protein A1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Formalin/Paraffin, Immunoprecipitation (IP). WB: 1: 1000-1: 2000 IHC (paraffin): 1: 1000-1: 5000 IP: 1: 50-1: 200. Researchers should empirically determine the suitability of the Bcl2a1a bcl2a1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Bcl-2 related protein A1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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