Western Blot (WB)
(Western Blot: Sample: Rat Serum; Primary Ab: 1ug/ml Rabbit Anti-Rat Bcl2L Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Rabbit anti-Rat B-Cell CLL/Lymphoma 2 Like Protein (Bcl2L) Polyclonal Antibody | anti-Bcl2L antibody
Polyclonal Antibody to B-Cell CLL/Lymphoma 2 Like Protein (Bcl2L)
MGHHHHHHSGSEF-SQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEE TEPERETPSA INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR YRRAFSDLTS QLHITPGTAY QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL CVESVDKEMQ VLVSRIASWM ATYLNDHLEP WIQENGGWDT FVDLYGNNAA AESRKGQERF NR
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Rat Serum; Primary Ab: 1ug/ml Rabbit Anti-Rat Bcl2L Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Western Blot (WB)
(Western Blot: Sample: Rat Serum; Primary Ab: 1ug/ml Rabbit Anti-Rat Bcl2L Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P. Samples: Rat Tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P. Samples: Rat Tissue))
NCBI and Uniprot Product Information
NCBI Description
inhibits neuronal apoptosis; may provide neuroprotection against ischemic brian injury [RGD, Feb 2006]
Uniprot Description
Bcl-xL: an antiapoptotic member of the Bcl-2 family. Located at the outer mitochondrial membrane and regulates outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are potent inducers of cell apoptosis. Two alternatively spliced isoforms have been reported.
Protein type: Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial
Chromosomal Location of Human Ortholog: 3q41
Cellular Component: cell junction; centrosome; clathrin-coated pit; cytoplasm; cytosol; endoplasmic reticulum; integral component of membrane; intracellular; membrane; mitochondrial envelope; mitochondrial inner membrane; mitochondrial matrix; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; nuclear membrane; presynapse; synaptic vesicle membrane
Molecular Function: BH domain binding; BH3 domain binding; caspase inhibitor activity; clathrin binding; GTPase binding; identical protein binding; protein binding; protein complex binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; transcription factor binding
Biological Process: aging; apoptosis; apoptotic process in bone marrow; cell proliferation; cellular process regulating host cell cycle in response to virus; cellular response to alkaloid; cellular response to astaxanthin; cellular response to cAMP; cellular response to dexamethasone stimulus; cellular response to gamma radiation; cellular response to hypoxia; cellular response to interleukin-1; cellular response to prolactin; cellular response to thapsigargin; cellular response to tumor necrosis factor; cerebral cortex development; DNA damage response, signal transduction resulting in induction of apoptosis; endocytosis; fertilization; germ cell development; growth; in utero embryonic development; male gonad development; mitotic cell cycle checkpoint; negative regulation of anoikis; negative regulation of apoptosis; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of execution phase of apoptosis; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of neuron apoptosis; negative regulation of release of cytochrome c from mitochondria; neuron apoptosis; ovarian follicle development; positive regulation of apoptosis; positive regulation of ATP biosynthetic process; positive regulation of cell proliferation; positive regulation of synaptic vesicle clustering; positive regulation of synaptic vesicle endocytosis; positive regulation of synaptic vesicle exocytosis; regulation of apoptosis; regulation of long term synaptic depression; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; release of cytochrome c from mitochondria; response to cycloheximide; response to cytokine; response to drug; response to electrical stimulus; response to hydrogen peroxide; response to hypoxia; response to inorganic substance; response to lead ion; response to lipopolysaccharide; response to organic cyclic compound; response to organonitrogen compound; response to oxidative stress; response to peptide hormone; response to radiation; response to virus; spermatogenesis; suppression by virus of host apoptotic process; synaptic vesicle recycling via endosome
Research Articles on Bcl2L
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Product Notes
The Bcl2L bcl2l1 (Catalog #AAA2002780) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to B-Cell CLL/Lymphoma 2 Like Protein (Bcl2L) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's B-Cell CLL/Lymphoma 2 Like Protein (Bcl2L) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the Bcl2L bcl2l1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSG SEF-SQSNRE LVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEE TEPERETPSA INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR YRRAFSDLTS QLHITPGTAY QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL CVESVDKEMQ VLVSRIASWM ATYLNDHLEP WIQENGGWDT FVDLYGNNAA AESRKGQERF NR. It is sometimes possible for the material contained within the vial of "B-Cell CLL/Lymphoma 2 Like Protein (Bcl2L), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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