Knockout Validation
(Knockout Validation: Lane 1: Wild-type 293T cell lysate; Lane 2: AZU1 knockout 293T cell lysate; Predicted MW: 27kd Observed MW: 27kd Primary Ab: 1ug/ml Rabbit Anti-Human AZU1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Rabbit anti-Human Azurocidin 1 (AZU1) Polyclonal Antibody | anti-AZU1 antibody
Cy3-Linked Polyclonal Antibody to Azurocidin 1 (AZU1)
Knockout Validation
(Knockout Validation: Lane 1: Wild-type 293T cell lysate; Lane 2: AZU1 knockout 293T cell lysate; Predicted MW: 27kd Observed MW: 27kd Primary Ab: 1ug/ml Rabbit Anti-Human AZU1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Knockout Validation
(Knockout Validation: Lane 1: Wild-type 293T cell lysate; Lane 2: AZU1 knockout 293T cell lysate; Predicted MW: 27kd Observed MW: 27kd Primary Ab: 1ug/ml Rabbit Anti-Human AZU1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
NCBI and Uniprot Product Information
NCBI Description
Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Nov 2015]
Uniprot Description
AZU1: This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram- negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G. Belongs to the peptidase S1 family. Elastase subfamily.
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: azurophil granule; extracellular space; extrinsic to membrane
Molecular Function: heparan sulfate proteoglycan binding; heparin binding; peptidase activity; protein binding; serine-type endopeptidase activity
Biological Process: antimicrobial humoral response; defense response to Gram-negative bacterium; defense response to virus; glial cell migration; microglial cell activation; monocyte activation; positive regulation of cell adhesion; positive regulation of fractalkine biosynthetic process; positive regulation of interleukin-1 beta biosynthetic process; positive regulation of MHC class II biosynthetic process; positive regulation of phagocytosis; positive regulation of protein kinase activity; positive regulation of tumor necrosis factor biosynthetic process; protein kinase C activation; protein processing; proteolysis
Research Articles on AZU1
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Product Notes
The AZU1 azu1 (Catalog #AAA2055427) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cy3-Linked Polyclonal Antibody to Azurocidin 1 (AZU1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Azurocidin 1 (AZU1) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA). Researchers should empirically determine the suitability of the AZU1 azu1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Azurocidin 1 (AZU1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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