Structure
U0126, Inhibitor
U0126
Purity
>98% (HPLC)
Synonyms
U0126; U0126-EtOH; U 0126; U-0126; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=49mg/mL
Target
MEK
Receptor
CDK2; CDK4; MEK1; MEK2; PKC
Chemical Name
Butanedinitrile, 2, 3-bis[amino[(2-aminophenyl)thio]methylene]-, compd. with ethanol(1:1)
SMILES
CCO.C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N
Molecular Formula
C20H22N6OS2
CAS Number
1173097-76-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for U0126, inhibitor
U0126 (U0126-EtOH) is a potent, selective MEK (MAP2K) inhibitor with IC50 of 70nM and 60nM for MEK1 and MEK2, suppresses AP-1-mediated gene activation in transient transfection assays with IC50 of 0.96uM; shows little to no effect on the kinase activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2, or Cdk4; inhibits T cell proliferation in response to antigenic stimulation or cross-linked anti-CD3 plus anti-CD28 Abs, but has no effect on IL-2-induced proliferation; reduces tumor size of tumor xenografts in nude mice.
Product Categories/Family for U0126, inhibitor
References
1. Favata MF, et al. J Biol Chem. 1998 Jul 17; 273 (29):18623-32.
2. DeSilva DR, et al. J Immunol. 1998 May 1; 160 (9):4175-81.
3. Bessard A, et al. Oncogene. 2008 Sep 11; 27 (40):5315-25.
4. Duncia JV, et al. Bioorg Med Chem Lett. 1998 Oct 20; 8 (20):2839-44.
2. DeSilva DR, et al. J Immunol. 1998 May 1; 160 (9):4175-81.
3. Bessard A, et al. Oncogene. 2008 Sep 11; 27 (40):5315-25.
4. Duncia JV, et al. Bioorg Med Chem Lett. 1998 Oct 20; 8 (20):2839-44.
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Product Notes
The U0126 (Catalog #AAA3600579) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "U0126, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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