Immunofluorescence (IF)
(Immunofluorescence analysis of A549 cells using ASCC3 antibody.)
Rabbit anti-Human, Mouse ASCC3 Polyclonal Antibody | anti-ASCC3 antibody
ASCC3 Polyclonal Antibody
IF: 1:50-1:100
Immunofluorescence (IF)
(Immunofluorescence analysis of A549 cells using ASCC3 antibody.)
Immunofluorescence (IF)
(Immunofluorescence analysis of A549 cells using ASCC3 antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Description
ASCC3: 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation. Belongs to the helicase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.6.4.12; Helicase; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 6q16
Cellular Component: Golgi apparatus; membrane; cytoplasm; intracellular; nucleus
Molecular Function: protein binding; ATP-dependent 3'-5' DNA helicase activity; ATP binding
Biological Process: cell proliferation; DNA dealkylation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; DNA duplex unwinding
Research Articles on ASCC3
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Product Notes
The ASCC3 ascc3 (Catalog #AAA9434219) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ASCC3 Polyclonal Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's ASCC3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). WB: 1:500-1:2000 IF: 1:50-1:100. Researchers should empirically determine the suitability of the ASCC3 ascc3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ASCC3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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