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Immunohistochemistry (IHC)

Rabbit anti-Human Activating signal cointegrator 1 complex subunit 3 Polyclonal Antibody | anti-ASCC3 antibody

Rabbit anti-human Activating signal cointegrator 1 complex subunit 3 polyclonal Antibody(ASCC3)

Gene Names
ASCC3; RNAH; HELIC1; ASC1p200
Reactivity
Human
Applications
ELISA, Immunohistochemistry
Purity
Antigen Affinity Purified
Synonyms
Activating signal cointegrator 1 complex subunit 3; Polyclonal Antibody; Rabbit anti-human Activating signal cointegrator 1 complex subunit 3 polyclonal Antibody(ASCC3); ASC-1 complex subunit p200; ASC1p200; Helicase; ATP binding 1; Trip4 complex subunit p200; ASCC3; HELIC1; anti-ASCC3 antibody
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For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen Affinity Purified
Sequence Length
731
Applicable Applications for anti-ASCC3 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes
Recommended dilution: IHC:1:20-1:200
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Activating signal cointegrator 1 complex subunit 3 protein (1-111aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-68558 / sc-68559
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human breast cancer using MBS1497017 at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human placenta using MBS1497017 at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human pancreas using MBS1497017 at dilution 1:100)

Related Product Information for anti-ASCC3 antibody
3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Enhances NF-kappa-B, SRF and AP1 transactivation.1 Publication

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
83,675 Da
NCBI Official Full Name
activating signal cointegrator 1 complex subunit 3 isoform c
NCBI Official Synonym Full Names
activating signal cointegrator 1 complex subunit 3
NCBI Official Symbol
ASCC3
NCBI Official Synonym Symbols
RNAH; HELIC1; ASC1p200
NCBI Protein Information
activating signal cointegrator 1 complex subunit 3
UniProt Protein Name
Activating signal cointegrator 1 complex subunit 3
Protein Family
UniProt Gene Name
ASCC3
UniProt Synonym Gene Names
HELIC1; ASC1p200
UniProt Entry Name
ASCC3_HUMAN

NCBI Description

This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Uniprot Description

ASCC3: 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation. Belongs to the helicase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.4.12; Helicase; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 6q16

Cellular Component: cytoplasm; Golgi apparatus; intracellular; membrane; nucleoplasm; nucleus

Molecular Function: ATP binding; ATP-dependent 3'-5' DNA helicase activity; protein binding

Biological Process: cell proliferation; DNA dealkylation; DNA duplex unwinding; DNA repair; regulation of transcription, DNA-dependent; transcription, DNA-dependent

Research Articles on ASCC3

1. Silencing of ASCC3 resulted in upregulation of multiple antiviral interferon-stimulated genes, which correlated with inhibition of infection of several positive-strand RNA viruses.

Similar Products

ASCC3 Recombinant Protein

Host: E Coli or Yeast or Baculovirus or Mammalian Cell
Reactivity: n/a
Apps: n/a

ASCC3 Antibody

Host: Rabbit
Reactivity: Human, Mouse, Rat
Apps: ELISA, Western Blot

ASCC3 Antibody

Host: Rabbit
Reactivity: Human
Apps: Western Blot, Immunofluorescence

HELIC1 Antibody

Host: Rabbit
Reactivity: Human, Mouse
Apps: Western Blot, Immunofluorescence, Immunocytochemistry

ASCC3 ELISA Kit

Host: n/a
Reactivity: Human
Apps: n/a

ASCC3 ELISA Kit

Host: n/a
Reactivity: Human
Apps: n/a

ASCC3 ELISA Kit

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Product Notes

The ASCC3 ascc3 (Catalog #AAA1497017) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Activating signal cointegrator 1 complex subunit 3 polyclonal Antibody(ASCC3) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Activating signal cointegrator 1 complex subunit 3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Recommended dilution: IHC:1:20-1:200. Researchers should empirically determine the suitability of the ASCC3 ascc3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Activating signal cointegrator 1 complex subunit 3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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